About: Positřive association of adiponectin with soluble vascular cell adhesion molecule sVCAM-1 levels in patients with vascular disease or dyslipidemia

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of our study was to evaluate the relationship of adiponectin to soluble forms of vascular cell adhesion molecule-l (sVCAM-1) and intercellular cell adhesion molecule-1 (sICAM-1) in patients with cardiovascular disease or dyslipidemia. Two hundred and sixty-four patients (134 men/130 women, mean age 43,8?14,8/46,0?14,9 years) of Lipid Center, University Hospital Olomouc, off hypolipidemic therapy for at least 6 weeks, participated in the study. In multiple regression analysis, adiponectin was independently positively associated with serum HDL-cholesterol (p<0,0001) and sVCAM-1 (p<0,0001), female gender (p<0,0001) and negatively with hs-CRP (p=0,014). Serum concentration of adiponectin and sICAM-1 did not correlate but sICAM-1 was independently, positively associated with sVCAM-1 (p<0,0001) and negatively with markers of insulin resistance and inflammation, namely atherogenic index log(triglycerides/HDL-cholesterol) (p<0,0001), hs-CRP (p<0,001) and HOMA (p<0,05). Positive The aim of our study was to evaluate the relationship of adiponectin to soluble forms of vascular cell adhesion molecule-l (sVCAM-1) and intercellular cell adhesion molecule-1 (sICAM-1) in patients with cardiovascular disease or dyslipidemia. Two hundred and sixty-four patients (134 men/130 women, mean age 43,8?14,8/46,0?14,9 years) of Lipid Center, University Hospital Olomouc, off hypolipidemic therapy for at least 6 weeks, participated in the study. In multiple regression analysis, adiponectin was independently positively associated with serum HDL-cholesterol (p<0,0001) and sVCAM-1 (p<0,0001), female gender (p<0,0001) and negatively with hs-CRP (p=0,014). Serum concentration of adiponectin and sICAM-1 did not correlate but sICAM-1 was independently, positively associated with sVCAM-1 (p<0,0001) and negatively with markers of insulin resistance and inflammation, namely atherogenic index log(triglycerides/HDL-cholesterol) (p<0,0001), hs-CRP (p<0,001) and HOMA (p<0,05). Positive (en) Cílem naší práce bylo zhodnotit vztah adiponektinu k solubilním formám adhezivních molekul sVCAM-1 a sICAM-1 u pacientů s přítomností kardiovaskulárního onemocnění nebo s dyslipidémií. Studie se zúčastnilo 264 pacientů (134 mužů/130 žen, průměrný věk 43,8?14,8 let) lipidové poradny Fakultní nemocnice Olomouc, kteří nebyli v posledních 6 týdnech léčeni hypolipidemickou léčbou. V mnohonásobné regresní analýze byl adiponektin nezávisle pozitivně asociován s hladinami HDL-cholesterolu (p<0,0001) a sVCAM-1 (p<0,0001), s ženským pohlavím (p<0,0001) a negativně s hs-CRP (p=0,014). Sérové koncentrace sICAM-1 nekorelovaly s hladinami adiponektinu, ale korelovaly pozitivně se sVCAM-1 (p<0,0001) a negativně s markery inzulínové rezistence a zánětu, zejména s aterogenním indexem log(triglyceridy/HDL-cholesterol) (p<0,0001), hs-CRP (p<0,001) a HOMA (p<0,05). Pozitivní asociace adiponektinu s HDL-cholesterolem a negativní asociace s hs-CRP ukazuje na antiaterogenní vlastnosti adiponektinu. (cs)
Title	Positřive association of adiponectin with soluble vascular cell adhesion molecule sVCAM-1 levels in patients with vascular disease or dyslipidemia Positřive association of adiponectin with soluble vascular cell adhesion molecule sVCAM-1 levels in patients with vascular disease or dyslipidemia (en) Pozitivní asociace adiponektinu se solubilními adhezivními molekulami sVCAM-1 u pacientů s cévním onemocněním nebo s dyslipidémií (cs)
skos:prefLabel	Positřive association of adiponectin with soluble vascular cell adhesion molecule sVCAM-1 levels in patients with vascular disease or dyslipidemia Positřive association of adiponectin with soluble vascular cell adhesion molecule sVCAM-1 levels in patients with vascular disease or dyslipidemia (en) Pozitivní asociace adiponektinu se solubilními adhezivními molekulami sVCAM-1 u pacientů s cévním onemocněním nebo s dyslipidémií (cs)
skos:notation	RIV/61989592:15110/08:00006111!RIV09-MZ0-15110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR9068)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	VAVERKOVÁ, Helena KARÁSEK, David Halenka, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	387754
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/08:00006111
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	adiponectin; sVCAM-1; sICAM-1; insulin resistance; inflammation; hs-CRP; dyslipidemia (en)
http://linked.open.../riv/klicoveSlovo	hs-CRP inflammation adiponectin insulin resistance dyslipidemia sICAM-1 sVCAM-1
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[3CC678581D25]
http://linked.open...i/riv/nazevZdroje	Atherosclerosis
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Dyslipidemia classification based on concentration of apolipoprotein B and triglycerides. Association of dyslipidemic phenotypes with indices of insulin resistance, inflammation and thrombosis, subclinical and clinical atherosclerosis and DNA markers.
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	197
http://linked.open...iv/tvurceVysledku	Vaverková, Helena Halenka, Milan Karásek, David Novotný, Dalibor Lukeš, Jiří Frohlich, Jiří Jackuliaková, Dagmar
issn	1567-5688
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	15110
is http://linked.open...avai/riv/vysledek of	Positřive association of adiponectin with soluble vascular cell adhesion molecule sVCAM-1 levels in patients with vascular disease or dyslipidemia Positřive association of adiponectin with soluble vascular cell adhesion molecule sVCAM-1 levels in patients with vascular disease or dyslipidemia Positřive association of adiponectin with soluble vascular cell adhesion molecule sVCAM-1 levels in patients with vascular disease or dyslipidemia Positřive association of adiponectin with soluble vascular cell adhesion molecule sVCAM-1 levels in patients with vascular disease or dyslipidemia

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