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| Description
| - Byl studován vliv extraktu z borůvek (25% anthokyaninů) na poškození primárních kultur potkaních hepatocytů terc-butylhydroperoxidem a allylalkoholem. Extrakt v koncentraci 100 a 500 ?g/ml vykazoval cytoprotektivní účinek v MTT testu životnosti buněk, chránil buněčnou membránu (snížené uvolňování laktátdehydrogenasy) a potlačoval tvorbu produktů lipoperoxidace. Nejvyšší ochranný účinek se projevil v koncentraci extraktu 500 ?g/ml při intoxikaci allyalkoholem. Pozorovaný účinek je pravděpodobně dán antioxidačními vlastnostmi složek extraktu, zejména anthokyaninů. Extrakt zhášel DPPH (IC50 3,99 ? 0,14 ?g/ml) a neenzymaticky generovaný superoxidový anion radikál (aktivita ekvivalentní 108 ? 7,2 U superoxiddismutasy na mg extraktu). Naše výsledky podporují používání borůvek a extraktů z nich ve funkčních potravinách a doplňcích stravy určených pro prevenci chronických onemocnění spojených s oxidačním stresem. (cs)
- The effect of a bilberry extract (BE, 25% anthocyanins) against oxidative damage in primary cultures of rat hepatocytes, induced by tert-butyl hydroperoxide and allyl alcohol, was investigated. BE displayed cytoprotective effects at 100 and 500 μg/ml in the MTT viability test. It protected the cells against lactate dehydrogenase leakage and lipoperoxidation products formation. Maximum protection (58%) was noted using 500 μg/ml of BE and intoxication by allyl alcohol. The observed cytoprotective effect is probably due to the antioxidant properties of its constituents, mainly anthocyanins. BE scavenged DPPH (IC50 3.99 ? 0.14 μg/ml) and enzymatically generated superoxide radical with an activity equivalent to 108 ? 7.2 U of superoxide dismutase per mg of extract. Our results support the use of bilberry and bilberry extracts in functional foods and food supplements designed for the prevention of chronic diseases associated with oxidative stress.
- The effect of a bilberry extract (BE, 25% anthocyanins) against oxidative damage in primary cultures of rat hepatocytes, induced by tert-butyl hydroperoxide and allyl alcohol, was investigated. BE displayed cytoprotective effects at 100 and 500 μg/ml in the MTT viability test. It protected the cells against lactate dehydrogenase leakage and lipoperoxidation products formation. Maximum protection (58%) was noted using 500 μg/ml of BE and intoxication by allyl alcohol. The observed cytoprotective effect is probably due to the antioxidant properties of its constituents, mainly anthocyanins. BE scavenged DPPH (IC50 3.99 ? 0.14 μg/ml) and enzymatically generated superoxide radical with an activity equivalent to 108 ? 7.2 U of superoxide dismutase per mg of extract. Our results support the use of bilberry and bilberry extracts in functional foods and food supplements designed for the prevention of chronic diseases associated with oxidative stress. (en)
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| Title
| - Cytoprotective effect of a bilberry extract against oxidative damage of rat hepatocytes
- Cytoprotective effect of a bilberry extract against oxidative damage of rat hepatocytes (en)
- Cytoprotektivní účinek extraktu z borůvek proti oxidačnímu poškození potkaních hepatocytů (cs)
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| skos:prefLabel
| - Cytoprotective effect of a bilberry extract against oxidative damage of rat hepatocytes
- Cytoprotective effect of a bilberry extract against oxidative damage of rat hepatocytes (en)
- Cytoprotektivní účinek extraktu z borůvek proti oxidačnímu poškození potkaních hepatocytů (cs)
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| skos:notation
| - RIV/61989592:15110/07:00003546!RIV08-MPO-15110___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(FT-TA3/024), Z(MSM6198959216)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/07:00003546
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Vaccinium myrtillus; Cytoprotectivity; Radical scavenging (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Ulrichová, Jitka
- Valentová, Kateřina
- Šimánek, Vilím
- Cvak, Ladislav
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| http://linked.open...n/vavai/riv/zamer
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| number of pages
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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