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| rdf:type
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| Description
| - Glucocorticoid receptor (GR) and aryl hydrocarbon receptor (AhR) are two entirely different individuals, the former being a typical steroid receptor integrated in endogenous affairs, the latter being the first described xeno-receptor, so-called dioxin receptor. Interestingly, these two receptors share several common features: 1) involvement in essential cellular processes such as proliferation, differentiation, inflammatory response, and gene expression; 2) essential role in drug metabolism, i.e. direct and/or indirect control of phase I, II, and III enzymes expression. 3) mechanism of their action in terms of ligand binding, nuclear import and export, and proteasome-mediated degradation, the last feature serving as negative feedback. 4) The dependence of their activity on the status of microtubules network. Despite voluminous data published, the role of microtubules in GR signaling is still controversial. Crucial appears the distinction between proliferating versus non-proliferating cells. While pert
- Glucocorticoid receptor (GR) and aryl hydrocarbon receptor (AhR) are two entirely different individuals, the former being a typical steroid receptor integrated in endogenous affairs, the latter being the first described xeno-receptor, so-called dioxin receptor. Interestingly, these two receptors share several common features: 1) involvement in essential cellular processes such as proliferation, differentiation, inflammatory response, and gene expression; 2) essential role in drug metabolism, i.e. direct and/or indirect control of phase I, II, and III enzymes expression. 3) mechanism of their action in terms of ligand binding, nuclear import and export, and proteasome-mediated degradation, the last feature serving as negative feedback. 4) The dependence of their activity on the status of microtubules network. Despite voluminous data published, the role of microtubules in GR signaling is still controversial. Crucial appears the distinction between proliferating versus non-proliferating cells. While pert (en)
- Glukokortikoidní receptor (GR) a aryl uhlovodíkový receptor (AhR) jsou dvě zcela odlišné entity, první z nich je typický steroidní receptor zapojený do endogenních pochodů, druhý z nich je první popsaný xenoreceptor, tzv. dioxinový receptor. Je zajímavé, že tyto dva receptory sdílejí několik společných vlastností: 1) zapojení do esenciálních buněčných procesů jakými jsou proliferace, diferenciace, zánětlivá reakce a exprese genů, 2) důležitá úloha v metabolismu léčiv, tj. přímá a/nebo nepřímá regulace exprese biotransformačních enzymů fáze I, II a III. 3) mechanismus jejich účinku ve smyslu vazby ligandu, import a export do/z jádra a protesomem řízená degradace, která slouží jako negativní regulace. 4) Závislost jejich aktivity na stavu mikrotubulární sítě. Navzdory objemnému souboru publikovaných dat je úloha mikrotubulární sítě v signalizaci GR stále kontroverzní. Rozhodující se zdá být odlišnost proliferujících a neproliferujících buněk. Ačkoli porušení mikrotubulární sítě v buňkách lidského karcin (cs)
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| Title
| - Microtubules network in glucocortocoid receptor and aryl hydrocarbon receptor signaling
- Microtubules network in glucocortocoid receptor and aryl hydrocarbon receptor signaling (en)
- Mikrotubulární síť v signalizaci glukokortikoidního a aryl uhlovodíkového receptoru. (cs)
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| skos:prefLabel
| - Microtubules network in glucocortocoid receptor and aryl hydrocarbon receptor signaling
- Microtubules network in glucocortocoid receptor and aryl hydrocarbon receptor signaling (en)
- Mikrotubulární síť v signalizaci glukokortikoidního a aryl uhlovodíkového receptoru. (cs)
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| skos:notation
| - RIV/61989592:15110/06:00003511!RIV07-MSM-15110___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/06:00003511
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - Glucocorticoid receptor; Aryl hydrocarbon receptor; Microtubules; Cellular signaling; Drug metabolism (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/mistoVydani
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| http://linked.open...i/riv/nazevZdroje
| - Focus on Cellular Signaling Research
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...iv/tvurceVysledku
| - Dvořák, Zdeněk
- Ulrichová, Jitka
- Modrianský, Martin
- Maurel, Patrick
- Vilarem, M. J.
- Pascussi, J. M.
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| http://linked.open...n/vavai/riv/zamer
| |
| number of pages
| |
| http://purl.org/ne...btex#hasPublisher
| - Nova Science Publisher, Inc.
|
| https://schema.org/isbn
| |
| http://localhost/t...ganizacniJednotka
| |
| is http://linked.open...avai/riv/vysledek
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