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| Description
| - Disruptory mikrotubulů, známější pod názvem antimitotika, mají široké uplatnění v humánní medicíně, nejčastěji jako antineoplastika. Tyto látky podléhají v lidském těle biotransformaci, která je obvykle katalyzována cytochromy P450. Proto jsou antimitotika možnou příčinou mezilékových interakcí jak na úrovni aktivity, tak exprese cytochromů P450. Toto review diskutuje účinky čtyř nejznámějších antimitotik přírodního původu: kolchicinu, taxolu (paklitaxelu), vinkristinu a vinblastinu, a také syntetického disruptoru mikrotubulů nokodazolu, na transkripční aktivitu glukokortikoidního a aryl hydrokarbonového receptoru. Literární data naznačují, že porušení mikrotubulů limituje signalizaci prováděnou těmito dvěma receptory a to nezávisle na fázi buněčného cyklu. Z toho vyplývá, že mikrotubuly hrají důležitou úlohu v regulaci exprese cytochromů P450, které jsou pod přímou či nepřímou kontrolou těchto dvou nukleárních receptorů. (cs)
- Microtubule disruptors, widely known as antimitotics, have broad applications in human medicine, especially as anti-neoplastic agents. They are subject to biotransformation within human body frequently involving cytochromes P450. Therefore antimitotics are potential culprits of drug-drug interactions on the level of activity as well as expression of cytochromes P450. This review discusses the effects of four well-known natural antimitotics: colchicine, taxol (paclitaxel), vincristine, and vinblastine, and a synthetic microtubule disruptor nocodazole on transcriptional activity of glucocorticoid and aryl hydrocarbon receptors. It appears that microtubules disarray restricts the signaling by these two nuclear receptors regardless of cell cycle phase. Consequently, intact microtubules play an important role in the regulation of expression of cytochromes P450, which are under direct or indirect control of the two nuclear receptors.
- Microtubule disruptors, widely known as antimitotics, have broad applications in human medicine, especially as anti-neoplastic agents. They are subject to biotransformation within human body frequently involving cytochromes P450. Therefore antimitotics are potential culprits of drug-drug interactions on the level of activity as well as expression of cytochromes P450. This review discusses the effects of four well-known natural antimitotics: colchicine, taxol (paclitaxel), vincristine, and vinblastine, and a synthetic microtubule disruptor nocodazole on transcriptional activity of glucocorticoid and aryl hydrocarbon receptors. It appears that microtubules disarray restricts the signaling by these two nuclear receptors regardless of cell cycle phase. Consequently, intact microtubules play an important role in the regulation of expression of cytochromes P450, which are under direct or indirect control of the two nuclear receptors. (en)
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| Title
| - Microtubule disruptors and their interaction with biotransformation enzymes
- Disruptory mikrotubulů a jejich interakce s biotransformačními enzymy (cs)
- Microtubule disruptors and their interaction with biotransformation enzymes (en)
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| skos:prefLabel
| - Microtubule disruptors and their interaction with biotransformation enzymes
- Disruptory mikrotubulů a jejich interakce s biotransformačními enzymy (cs)
- Microtubule disruptors and their interaction with biotransformation enzymes (en)
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| skos:notation
| - RIV/61989592:15110/05:00001919!RIV06-MSM-15110___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GP303/04/P074), Z(MSM6198959216)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/05:00001919
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Antimitotic drugs; Drug metabolism; Cytochromes P450; Nuclear receptors; Gene expression (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Dvořák, Zdeněk
- Modrianský, Martin
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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