About: Polymer brushes showing non-fouling in blood plasma challenge the currently accepted design of protein resistant surfaces

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Ultra-low-fouling poly[N-(2-hydroxypropyl) methacrylamide] (poly(HPMA)) brushes have been synthesized for the first time. Similar to the so far only ultra-low-fouling surface, poly(carboxybetaine acrylamide), the level of blood plasma fouling was below the detection limit of surface plasmon resonance (SPR, 0.03 ng cm2) despite being a hydrogen bond donor and displaying a moderate wettability, thus challenging the currently accepted views for the design of antifouling properties. The antifouling properties were preserved even after two years of storage. To demonstrate the potential of poly(HPMA) brushes for the preparation of bioactive ultra-low fouling surfaces a label-free SPR immunosensor for detection of G Streptococcus was prepared. Ultra-low-fouling poly[N-(2-hydroxypropyl) methacrylamide] (poly(HPMA)) brushes have been synthesized for the first time. Similar to the so far only ultra-low-fouling surface, poly(carboxybetaine acrylamide), the level of blood plasma fouling was below the detection limit of surface plasmon resonance (SPR, 0.03 ng cm2) despite being a hydrogen bond donor and displaying a moderate wettability, thus challenging the currently accepted views for the design of antifouling properties. The antifouling properties were preserved even after two years of storage. To demonstrate the potential of poly(HPMA) brushes for the preparation of bioactive ultra-low fouling surfaces a label-free SPR immunosensor for detection of G Streptococcus was prepared. (en)
Title	Polymer brushes showing non-fouling in blood plasma challenge the currently accepted design of protein resistant surfaces Polymer brushes showing non-fouling in blood plasma challenge the currently accepted design of protein resistant surfaces (en)
skos:prefLabel	Polymer brushes showing non-fouling in blood plasma challenge the currently accepted design of protein resistant surfaces Polymer brushes showing non-fouling in blood plasma challenge the currently accepted design of protein resistant surfaces (en)
skos:notation	RIV/61389013:_____/11:00360787!RIV12-AV0-61389013
http://linked.open...avai/predkladatel	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAAX00500803), P(KAN200670701), Z(AV0Z40500505)
http://linked.open...iv/cisloPeriodika	13
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Šubr, Vladimír Brynda, Eduard Houska, Milan Riedel, Tomáš Rodríguez-Emmenegger, Cesar Adolfo
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	221222
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/11:00360787
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	biosensors; blood plasma; HPMA (en)
http://linked.open.../riv/klicoveSlovo	biosensors blood plasma HPMA
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[EF3312EDE03B]
http://linked.open...i/riv/nazevZdroje	Macromolecular Rapid Communications
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Surface plasmon resonance biosensors and protein arrays for medical diagnostics Multifunctional Polymer Systems with Cytostatic and Immunomobilizing Activities
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Brynda, Eduard Šubr, Vladimír Houska, Milan Bologna Alles, A. Rodríguez-Emmenegger, Cesar Adolfo Gautrot, J. E. Hasan, E. Huck, W. T. S. Riedel, Tomáš
http://linked.open...ain/vavai/riv/wos	000292547100002
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie
issn	1022-1336
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/marc.201100189
is http://linked.open...avai/riv/vysledek of	Polymer brushes showing non-fouling in blood plasma challenge the currently accepted design of protein resistant surfaces Polymer brushes showing non-fouling in blood plasma challenge the currently accepted design of protein resistant surfaces

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