About: Effect of radiotherapy and hyperthermia on the tumor accumulation of HPMA copolymer-based drug delivery systems

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Description	The results presented here show that HPMA copolymer-based drug delivery systems accumulate effectively in different types of tumors. In addition, they demonstrate that hyperthermia increases the tumor accumulation of the copolymers depending on the tumor model used, and that radiotherapy increases their tumor concentrations independent of the tumor model used. Based on these findings, we conclude that radiotherapy is an effective means for improving the tumor accumulation of (polymeric) drug delivery systems, and we propose that the combination of carrier-based chemotherapy with radiotherapy holds significant potential for implementation in combined modality anticancer therapy. The results presented here show that HPMA copolymer-based drug delivery systems accumulate effectively in different types of tumors. In addition, they demonstrate that hyperthermia increases the tumor accumulation of the copolymers depending on the tumor model used, and that radiotherapy increases their tumor concentrations independent of the tumor model used. Based on these findings, we conclude that radiotherapy is an effective means for improving the tumor accumulation of (polymeric) drug delivery systems, and we propose that the combination of carrier-based chemotherapy with radiotherapy holds significant potential for implementation in combined modality anticancer therapy. (en) Presentované výsledky ukazují, že systémy pro dopravu léčiv založené na HPMA kopolymerech se efektivně akumulují v různých typech nádorů. Hypertermie zvyšuje akumulaci kopolymerů v nádoru v závislosti na použitém nádorovém modelu, zatímco při radioterapii akumulace vzrůstá nezávisle na nádorové linii. Na základě těchto poznatků lze usuzovat, že radioterapie je účinný prostředek pro zlepšení akumulace polymerních systémů pro dopravu léčiv v nádorech. Chemoterapie založená na kombinaci polymerního nosičového systému léčiv a radioterapie má významné možnosti při kombinovaném způsobu protirakovinné léčby. (cs)
Title	Effect of radiotherapy and hyperthermia on the tumor accumulation of HPMA copolymer-based drug delivery systems Effect of radiotherapy and hyperthermia on the tumor accumulation of HPMA copolymer-based drug delivery systems (en) Vliv radioterapie a hypertermie na nádorovou akumulaci systemů pro dopravu léčiv založených na HPMA kopolymerech (cs)
skos:prefLabel	Effect of radiotherapy and hyperthermia on the tumor accumulation of HPMA copolymer-based drug delivery systems Effect of radiotherapy and hyperthermia on the tumor accumulation of HPMA copolymer-based drug delivery systems (en) Vliv radioterapie a hypertermie na nádorovou akumulaci systemů pro dopravu léčiv založených na HPMA kopolymerech (cs)
skos:notation	RIV/61389013:_____/07:00079223!RIV07-AV0-61389013
http://linked.open.../vavai/riv/strany	333;341
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/05/2255), Z(AV0Z40500505)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Ulbrich, Karel Šubr, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	419070
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/07:00079223
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HPMA; drug delivery; tumor targeting (en)
http://linked.open.../riv/klicoveSlovo	drug delivery HPMA tumor targeting
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[BA46D67AAB4E]
http://linked.open...i/riv/nazevZdroje	Journal of Controlled Release
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Polymer conjugates of drugs targeted with specific oligopeptides
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	117
http://linked.open...iv/tvurceVysledku	Ulbrich, Karel Šubr, Vladimír Lammers, T. Storm, G. Peschke, P. Hennink, W. Huber, P. Debus, J. Kühnlein, R.
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie
issn	0168-3659
number of pages	9 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Effect of radiotherapy and hyperthermia on the tumor accumulation of HPMA copolymer-based drug delivery systems Effect of radiotherapy and hyperthermia on the tumor accumulation of HPMA copolymer-based drug delivery systems Effect of radiotherapy and hyperthermia on the tumor accumulation of HPMA copolymer-based drug delivery systems

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