About: Immunocompatibility evaluation of hydrogel-coated polyimide implants for applications in regenerative medicine

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Immunocompatibility of gelatin-based hydrogels to be applied as implant coatings for local regenerative treatment has been studied. First, the bio- and immuno-acceptability of the methacrylamide-modified gelatin hydrogels per se was screened. The results indicated that the hydrogels support cell growth. Metabolic activity of normal cells and permanent cell lines representing various cell types (endothelial, epithelial, fibroblast, and monocyte/macrophage) cultivated on the gelatin hydrogels was moderately lower compared to cells cultivated on tissue culture plastic. The cells cultivated on the hydrogels produced identical cytokines as the control cells although at lower levels. Importantly, no inflammatory activity, measured by nitric oxide and pro-inflammatory cytokine (IL-1, IL-6, and TNF) production, was observed in peritoneal cells and monocyte/macrophage RAW 264.7 cell line cultivated on the hydrogels Immunocompatibility of gelatin-based hydrogels to be applied as implant coatings for local regenerative treatment has been studied. First, the bio- and immuno-acceptability of the methacrylamide-modified gelatin hydrogels per se was screened. The results indicated that the hydrogels support cell growth. Metabolic activity of normal cells and permanent cell lines representing various cell types (endothelial, epithelial, fibroblast, and monocyte/macrophage) cultivated on the gelatin hydrogels was moderately lower compared to cells cultivated on tissue culture plastic. The cells cultivated on the hydrogels produced identical cytokines as the control cells although at lower levels. Importantly, no inflammatory activity, measured by nitric oxide and pro-inflammatory cytokine (IL-1, IL-6, and TNF) production, was observed in peritoneal cells and monocyte/macrophage RAW 264.7 cell line cultivated on the hydrogels (en)
Title	Immunocompatibility evaluation of hydrogel-coated polyimide implants for applications in regenerative medicine Immunocompatibility evaluation of hydrogel-coated polyimide implants for applications in regenerative medicine (en)
skos:prefLabel	Immunocompatibility evaluation of hydrogel-coated polyimide implants for applications in regenerative medicine Immunocompatibility evaluation of hydrogel-coated polyimide implants for applications in regenerative medicine (en)
skos:notation	RIV/61388971:_____/14:00433022!RIV15-GA0-61388971
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP301/12/1254)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Říhová, Blanka Šírová, Milada Rossmann, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	20538
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/14:00433022
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	methacrylamide-modified gelatin; hydrogel; polyimide implant (en)
http://linked.open.../riv/klicoveSlovo	hydrogel methacrylamide-modified gelatin polyimide implant
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[7DECFE2256CB]
http://linked.open...i/riv/nazevZdroje	Journal of Biomedical Materials Research. Part A
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Overcoming Natural and Multidrug Resistance by Tumor-Selective Delivery of ABC Transporter/Bcl-2 Inhibitors or Therapeutic Gene under PEG-3 Promoter
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	102
http://linked.open...iv/tvurceVysledku	Říhová, Blanka Šírová, Milada Dubruel, P. Rossmann, Pavel Schacht, E. van Vlierberghe, S. Matyášová, V.
http://linked.open...ain/vavai/riv/wos	000334488800036
issn	1549-3296
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/jbm.a.34873

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