About: Large propeptides of fungal β-N-acetylhexosaminidases are novel enzyme regulators that must be intracellularly processed to control activity, dimerization, and secretion into the extracellular environment

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About: Large propeptides of fungal β-N-acetylhexosaminidases are novel enzyme regulators that must be intracellularly processed to control activity, dimerization, and secretion into the extracellular environment Goto Sponge Distinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Vláknité houby produkují a sekretují β-N-acetylhexosaminidázy, Hex, jako důležité komponenty chitinolytického systému, který se účastní tvorby septa. Dříve publikované výsledky z rekonstitučních experimentů ukazují, že Hex se vyskytují ve dvou molekulárních formách obsahujících jednu či dvě molekuly propeptidu nekovalentně asociovaného s dimerizovaným enzymem. Zde popisujeme nový mechanizmus regulace aktivity Hex založený na asociaci katalytických podjednotek s velkým N-terminálním propeptidem in vivo (cs) Filamentous fungi produce and secrete β-N-acetylhexosaminidases, Hex, as important components of the binary chitinolytic systems involved in the formation of septa and hyphenation. Enzyme reconstitution experiments published previously indicate thet Hex can occur in the form of two molecular species containing either one or two molecules of the propeptide noncovalently associated with the enzyme dimer. Here, we describe a novel mechanism for the regulation of the activity of Hex based on the association of their catalytic subunits with the large N-terminal propetides in vivo Filamentous fungi produce and secrete β-N-acetylhexosaminidases, Hex, as important components of the binary chitinolytic systems involved in the formation of septa and hyphenation. Enzyme reconstitution experiments published previously indicate thet Hex can occur in the form of two molecular species containing either one or two molecules of the propeptide noncovalently associated with the enzyme dimer. Here, we describe a novel mechanism for the regulation of the activity of Hex based on the association of their catalytic subunits with the large N-terminal propetides in vivo (en)
Title	Large propeptides of fungal β-N-acetylhexosaminidases are novel enzyme regulators that must be intracellularly processed to control activity, dimerization, and secretion into the extracellular environment Velké propetidy fungální β-N-acetylhexosaminidázy jsou novými enzymovými regulátory, které pro aktivitu, dimerizaci a sektreci enzymu do vnějšího prostředí musí být intracelulárně zpracovány (cs) Large propeptides of fungal β-N-acetylhexosaminidases are novel enzyme regulators that must be intracellularly processed to control activity, dimerization, and secretion into the extracellular environment (en)
skos:prefLabel	Large propeptides of fungal β-N-acetylhexosaminidases are novel enzyme regulators that must be intracellularly processed to control activity, dimerization, and secretion into the extracellular environment Velké propetidy fungální β-N-acetylhexosaminidázy jsou novými enzymovými regulátory, které pro aktivitu, dimerizaci a sektreci enzymu do vnějšího prostředí musí být intracelulárně zpracovány (cs) Large propeptides of fungal β-N-acetylhexosaminidases are novel enzyme regulators that must be intracellularly processed to control activity, dimerization, and secretion into the extracellular environment (en)
skos:notation	RIV/61388971:_____/07:00089093!RIV08-AV0-61388971
http://linked.open.../vavai/riv/strany	2719;2734
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/04/1045), P(GA203/05/0172), P(GA204/06/0771), P(IAA5020403), P(LC06010), P(LC545), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Plíhal, Ondřej Weignerová, Lenka Bezouška, Karel Sklenář, Jan Kavan, Daniel Man, Petr Novák, Petr Křen, Vladimír Hofbauerová, Kateřina Pompach, Petr Pišvejcová, Andrea
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	430552
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/07:00089093
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	enzyme regulator; filamentous fungi; hex (en)
http://linked.open.../riv/klicoveSlovo	enzyme regulator hex filamentous fungi
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[70F4C2DF7CA2]
http://linked.open...i/riv/nazevZdroje	Biochemistry
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	11 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Biocatalysis and Biotransformation Functional Organisation of the Cell Cloning, expression and engineering of beta-N-acetylhexosaminidase suitable for chemoenzymatic synthesis of new oligosaccharides a-N-Acetylgalactosaminidase and a-galactosidase-structural and functional characterisation, use in synthesis of biologically important glycoconjugates The use of surface glycosylation in the immune recognition and elimination of tumors Tumor stress-induced proteins as target structures for cytotoxic cells
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	46
http://linked.open...iv/tvurceVysledku	Bezouška, Karel Hofbauerová, Kateřina Kavan, Daniel Křen, Vladimír Man, Petr Novák, Petr Plíhal, Ondřej Sklenář, Jan Pompach, Petr Ryšlavá, H. Weignerová, Lenka Charvátová, Andrea
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	0006-2960
number of pages	16 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Large propeptides of fungal β-N-acetylhexosaminidases are novel enzyme regulators that must be intracellularly processed to control activity, dimerization, and secretion into the extracellular environment Large propeptides of fungal β-N-acetylhexosaminidases are novel enzyme regulators that must be intracellularly processed to control activity, dimerization, and secretion into the extracellular environment Large propeptides of fungal β-N-acetylhexosaminidases are novel enzyme regulators that must be intracellularly processed to control activity, dimerization, and secretion into the extracellular environment

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