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Description
  • Intracelulární distribuce a účinek polymerních konjugátů na bázi N-(2-hydroxypropyl)metakrylamidu nesoucího cytostatikum doxorubicin je závislý na jejich struktuře. Zatímco konjugáty s hydrolyticky štěpitelnou vazbou mezi polymerním nosičem a léčivem napadají jádro a jejich účinek se blíží účinkům volného léčiva, polymery nesoucí doxorubicin navázaný pomocí enzymaticky štěpitelné spojky narušují spíše membránový systém buněk a mechanismus jejich cytotoxického účinku je tak zcela jiný. (cs)
  • Intracellular destiny and pharmacological effect of conjugates based on N-(2-hydroxypropyl)methacrylamide bearing doxorubicin is strongly influenced by their physico-chemical properties. Conjugates with doxorubicin attached via hydrolytically cleavable bond attack nuclear DNA and their effect is similar to free drug whereas conjugates with enzymatically cleavable spacer between drug and polymeric backbone desintegrates cellular membranes.
  • Intracellular destiny and pharmacological effect of conjugates based on N-(2-hydroxypropyl)methacrylamide bearing doxorubicin is strongly influenced by their physico-chemical properties. Conjugates with doxorubicin attached via hydrolytically cleavable bond attack nuclear DNA and their effect is similar to free drug whereas conjugates with enzymatically cleavable spacer between drug and polymeric backbone desintegrates cellular membranes. (en)
Title
  • Intracellular destiny of HPMA based non-targeted polymeric produgs
  • Intracelulární osud nesměrovaných polymerních léčiv na bázi HPMA (cs)
  • Intracellular destiny of HPMA based non-targeted polymeric produgs (en)
skos:prefLabel
  • Intracellular destiny of HPMA based non-targeted polymeric produgs
  • Intracelulární osud nesměrovaných polymerních léčiv na bázi HPMA (cs)
  • Intracellular destiny of HPMA based non-targeted polymeric produgs (en)
skos:notation
  • RIV/61388971:_____/04:00107937!RIV/2005/GA0/A53005/N
http://linked.open.../vavai/riv/strany
  • 190;191
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA305/02/1425), P(GP305/04/P004)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
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  • 568780
http://linked.open...ai/riv/idVysledku
  • RIV/61388971:_____/04:00107937
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • hpma;dmem (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [B23EC472305A]
http://linked.open...v/mistoKonaniAkce
  • Honolulu
http://linked.open...i/riv/mistoVydani
  • Honolulu
http://linked.open...i/riv/nazevZdroje
  • Annual Meeting and Exposition of the Controlled release Society /31./
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Etrych, Tomáš
  • Strohalm, Jiří
  • Ulbrich, Karel
  • Říhová, Blanka
  • Šubr, Vladimír
  • Hovorka, Ondřej
  • Zacharčenko, M.
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
number of pages
http://purl.org/ne...btex#hasPublisher
  • Neuveden
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