About: Mutations Conferring Resistance to Viral DNA Polymerase Inhibitors in Camelpox Virus Give Different Drug-Susceptibility Profiles in Vaccinia Virus     Goto   Sponge   Distinct   Permalink

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  • Drug resistance development among orthopoxviruses was studied. Both CMLV and VACV harboring the A314V change showed comparable drug-susceptibility profiles to various antivirals. In contrast, the single change T831I and the double change A314V+A684V in VACV were responsible for increased levels of drug resistance and for cross-resistance to viral DNA polymerase antivirals that were not observed with their CMLV counterparts.
  • Drug resistance development among orthopoxviruses was studied. Both CMLV and VACV harboring the A314V change showed comparable drug-susceptibility profiles to various antivirals. In contrast, the single change T831I and the double change A314V+A684V in VACV were responsible for increased levels of drug resistance and for cross-resistance to viral DNA polymerase antivirals that were not observed with their CMLV counterparts. (en)
Title
  • Mutations Conferring Resistance to Viral DNA Polymerase Inhibitors in Camelpox Virus Give Different Drug-Susceptibility Profiles in Vaccinia Virus
  • Mutations Conferring Resistance to Viral DNA Polymerase Inhibitors in Camelpox Virus Give Different Drug-Susceptibility Profiles in Vaccinia Virus (en)
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  • Mutations Conferring Resistance to Viral DNA Polymerase Inhibitors in Camelpox Virus Give Different Drug-Susceptibility Profiles in Vaccinia Virus
  • Mutations Conferring Resistance to Viral DNA Polymerase Inhibitors in Camelpox Virus Give Different Drug-Susceptibility Profiles in Vaccinia Virus (en)
skos:notation
  • RIV/61388963:_____/12:00377813!RIV13-AV0-61388963
http://linked.open...avai/predkladatel
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  • I
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  • 13
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  • 152548
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  • RIV/61388963:_____/12:00377813
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  • camelpox virus; CMLV; vaccinia virus VACV; acyclic nucleoside phosphonates; HPMPDAP; cidofovir; drug resistance (en)
http://linked.open.../riv/klicoveSlovo
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  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [CB0E5883B7A0]
http://linked.open...i/riv/nazevZdroje
  • Journal of Virology
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  • 86
http://linked.open...iv/tvurceVysledku
  • Andrei, G.
  • Krečmerová, Marcela
  • Snoeck, R.
  • Topalis, D.
  • Crance, J. M.
  • Duraffour, S.
  • Garin, D.
http://linked.open...ain/vavai/riv/wos
  • 000305501600029
issn
  • 0022-538X
number of pages
http://bibframe.org/vocab/doi
  • 10.1128/JVI.00355-12
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