About: Capillary electrophoretic and thin-layer chromatographic characterization of rhenium complexation with 1-hydroxyethylidenediphosphonic acid

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	1-Hydroxyethylidenediphosphonic acid (HEDP), labeled by short-lived radionuclides with the nuclear properties suitable for the therapeutical purposes (186Fe, 188Ho) is similar to the other phosphonates widely applied in the radiopharmaceutical field for the treatment of palliative bone metastases. One of the important steps for the preparation of compounds of radipharmaceutical interest is the quality control comprehending the radiochemical and chemical purity determination. Chromatographic methods as TLC and HPLC are mostly used for this purpose. Our experiments were focused on the application of capillary electrophoresis with UV detection to the study of rhenium complexation with HEDP. The influence of pH, concentration of the ligand and the reactiontime were determined. Taking in account our previous results, the Re:SnCl2 molar ratio 1.500 (for 0.1 mM Re) was applied to reduce perrhenate to lewer oxidation states which enables the Re-HEDP complexation. Different backround electrolytes were tested. 1-Hydroxyethylidenediphosphonic acid (HEDP), labeled by short-lived radionuclides with the nuclear properties suitable for the therapeutical purposes (186Fe, 188Ho) is similar to the other phosphonates widely applied in the radiopharmaceutical field for the treatment of palliative bone metastases. One of the important steps for the preparation of compounds of radipharmaceutical interest is the quality control comprehending the radiochemical and chemical purity determination. Chromatographic methods as TLC and HPLC are mostly used for this purpose. Our experiments were focused on the application of capillary electrophoresis with UV detection to the study of rhenium complexation with HEDP. The influence of pH, concentration of the ligand and the reactiontime were determined. Taking in account our previous results, the Re:SnCl2 molar ratio 1.500 (for 0.1 mM Re) was applied to reduce perrhenate to lewer oxidation states which enables the Re-HEDP complexation. Different backround electrolytes were tested. (en)
Title	Capillary electrophoretic and thin-layer chromatographic characterization of rhenium complexation with 1-hydroxyethylidenediphosphonic acid Capillary electrophoretic and thin-layer chromatographic characterization of rhenium complexation with 1-hydroxyethylidenediphosphonic acid (en)
skos:prefLabel	Capillary electrophoretic and thin-layer chromatographic characterization of rhenium complexation with 1-hydroxyethylidenediphosphonic acid Capillary electrophoretic and thin-layer chromatographic characterization of rhenium complexation with 1-hydroxyethylidenediphosphonic acid (en)
skos:notation	RIV/60461373:22340/03:00007465!RIV/2004/GA0/223404/N
http://linked.open.../vavai/riv/strany	317-323
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/00/D014), Z(MSM 223400008)
http://linked.open...iv/cisloPeriodika	990
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Kohlíčková, Michaela Křížová, Věra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	600334
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/03:00007465
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Rhenium; Metal complexes; Hydroxyethylidenediphosphonic acids; Phosphonic acids (en)
http://linked.open.../riv/klicoveSlovo	Rhenium Metal complexes Hydroxyethylidenediphosphonic acids Phosphonic acids
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[79D27A3C6482]
http://linked.open...i/riv/nazevZdroje	Journal of Chromatography A
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Utilisation of bacteriological and limnological bioassays with marine microorganisms in ecotoxicological monitoring of areas contaminated with organic
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	990
http://linked.open...iv/tvurceVysledku	Křížová, Věra Koudelková, Michaela
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20223400008
issn	0021-9673
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	22340

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