About: Anticoagulating Activities of Low-Molecular Weight Fuco-Oligosaccharides Prepared by Enzymatic Digestion of Fucoidan from the Sporophyll of Korean Undaria pinnatifida

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About: Anticoagulating Activities of Low-Molecular Weight Fuco-Oligosaccharides Prepared by Enzymatic Digestion of Fucoidan from the Sporophyll of Korean Undaria pinnatifida Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In spite of their potential as biologically active compounds, the high molecular mass and viscous natures of fucoidans have hampered their applications especially as a therapeutic agent. Herein the fucoidan-degrading enzyme activities were partially purified from the cultured cells of Sphingomonas paucimobilis PF-1 mainly by ammonium sulfate precipitation. This enzyme preparation degraded fucoidans from the Korean Undaria pinnatifida sporophyll into several low-molecular weight fuco-oligosaccharides (LMFOs) with less than 3,749 Da. The FTIR spectra of intact fucoidan and mixture of LMFOs (1,389 similar to 3,749Da) showed no significant structural difference except for about 10% reduced level of sulfate esters in LMFOs. The LMFOs have exerted strong anticoagulating activities at which the activated partial thromboplastin time (APTT) and thrombin time (TT) were significantly prolonged, although 3 similar to 20 times weaker activities were observed than those of intact fucoidan. In addition, unlike intac In spite of their potential as biologically active compounds, the high molecular mass and viscous natures of fucoidans have hampered their applications especially as a therapeutic agent. Herein the fucoidan-degrading enzyme activities were partially purified from the cultured cells of Sphingomonas paucimobilis PF-1 mainly by ammonium sulfate precipitation. This enzyme preparation degraded fucoidans from the Korean Undaria pinnatifida sporophyll into several low-molecular weight fuco-oligosaccharides (LMFOs) with less than 3,749 Da. The FTIR spectra of intact fucoidan and mixture of LMFOs (1,389 similar to 3,749Da) showed no significant structural difference except for about 10% reduced level of sulfate esters in LMFOs. The LMFOs have exerted strong anticoagulating activities at which the activated partial thromboplastin time (APTT) and thrombin time (TT) were significantly prolonged, although 3 similar to 20 times weaker activities were observed than those of intact fucoidan. In addition, unlike intac (en)
Title	Anticoagulating Activities of Low-Molecular Weight Fuco-Oligosaccharides Prepared by Enzymatic Digestion of Fucoidan from the Sporophyll of Korean Undaria pinnatifida Anticoagulating Activities of Low-Molecular Weight Fuco-Oligosaccharides Prepared by Enzymatic Digestion of Fucoidan from the Sporophyll of Korean Undaria pinnatifida (en)
skos:prefLabel	Anticoagulating Activities of Low-Molecular Weight Fuco-Oligosaccharides Prepared by Enzymatic Digestion of Fucoidan from the Sporophyll of Korean Undaria pinnatifida Anticoagulating Activities of Low-Molecular Weight Fuco-Oligosaccharides Prepared by Enzymatic Digestion of Fucoidan from the Sporophyll of Korean Undaria pinnatifida (en)
skos:notation	RIV/60461373:22330/10:00024317!RIV11-MSM-22330___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM6046137305)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Synytsya, Andriy
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta potravinářské a biochemické technologie
http://linked.open...dnocenehoVysledku	247090
http://linked.open...ai/riv/idVysledku	RIV/60461373:22330/10:00024317
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Fucoidan; Low-molecular weight fuco-oligosaccharides (LMFOs); Anticoagulating activity; Activated partial thromboplastin time (APTT) assay; Thrombin time (TT) assay (en)
http://linked.open.../riv/klicoveSlovo	Activated partial thromboplastin time (APTT) assay Anticoagulating activity Fucoidan Low-molecular weight fuco-oligosaccharides (LMFOs) Thrombin time (TT) assay
http://linked.open...odStatuVydavatele	KR - Korejská republika
http://linked.open...ontrolniKodProRIV	[405A33E2E48C]
http://linked.open...i/riv/nazevZdroje	ARCHIVES OF PHARMACAL RESEARCH
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	33
http://linked.open...iv/tvurceVysledku	Synytsya, Andriy Park, Jae Kweon Park, Yong Il Kim, Woo Jung Jung, Mi-Kyung Kim, Sung Min Kim, Yeong Shik Koo, Yean-Kyoung Moon, Hye Ran Yun-Choi, Hye Sook
http://linked.open...ain/vavai/riv/wos	000274052000016
http://linked.open...n/vavai/riv/zamer	Teoretické základy potravinářských a biochemických technologií
issn	0253-6269
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	22330
is http://linked.open...avai/riv/vysledek of	Anticoagulating Activities of Low-Molecular Weight Fuco-Oligosaccharides Prepared by Enzymatic Digestion of Fucoidan from the Sporophyll of Korean Undaria pinnatifida Anticoagulating Activities of Low-Molecular Weight Fuco-Oligosaccharides Prepared by Enzymatic Digestion of Fucoidan from the Sporophyll of Korean Undaria pinnatifida Anticoagulating Activities of Low-Molecular Weight Fuco-Oligosaccharides Prepared by Enzymatic Digestion of Fucoidan from the Sporophyll of Korean Undaria pinnatifida

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