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Description
| - Design, syntéza a studium modelu fotolyasy (cs)
- Two new artificial photolyase models that recognize pyrimidine dimers in protic and aprotic organic solvents as well as in water through a combination of charge and hydrogen bonding interactions and use a mimic of the flavine to achieve repair through reductive photoinduced electron transfer are presented. Flourescence and NMR titration studies show that it forms a 1:1 complex with pyrimidine dimers with binding constants of ~103 M-1 in acetonitrile or methanol, while binding constants in water at pH7.2 are slightly lower. Excitation of the complex with visible light leads to clean and rapid cycloreversion of the pyrimidine dimer through photoinduced electron transfer catalysis. The reaction in water is significantly faster than in organic solvents. The reaction slows down at higher conversions due to product inhibition.
- Two new artificial photolyase models that recognize pyrimidine dimers in protic and aprotic organic solvents as well as in water through a combination of charge and hydrogen bonding interactions and use a mimic of the flavine to achieve repair through reductive photoinduced electron transfer are presented. Flourescence and NMR titration studies show that it forms a 1:1 complex with pyrimidine dimers with binding constants of ~103 M-1 in acetonitrile or methanol, while binding constants in water at pH7.2 are slightly lower. Excitation of the complex with visible light leads to clean and rapid cycloreversion of the pyrimidine dimer through photoinduced electron transfer catalysis. The reaction in water is significantly faster than in organic solvents. The reaction slows down at higher conversions due to product inhibition. (en)
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Title
| - Design, Synthesis and Evaluation of a Biomimetic Artificial Photolyase Model
- Design, Synthesis and Evaluation of a Biomimetic Artificial Photolyase Model (en)
- Design, syntéza a studium modelu fotolyasy (cs)
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skos:prefLabel
| - Design, Synthesis and Evaluation of a Biomimetic Artificial Photolyase Model
- Design, Synthesis and Evaluation of a Biomimetic Artificial Photolyase Model (en)
- Design, syntéza a studium modelu fotolyasy (cs)
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skos:notation
| - RIV/60461373:22310/04:00011790!RIV/2005/MSM/223105/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60461373:22310/04:00011790
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Photolyase;enzyme models;flavin (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of Organic Chemistry
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Cibulka, Radek
- König, B.
- Harrison, C.
- Saettel, N.
- Sax, M.
- Wiest, O.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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