About: Rhodpsin 5- and Rhodopsin 6-mediated clock synchronization in Drosophila melanogaster in independent of retinal phospholipase C-beta signaling     Goto   Sponge   Distinct   Permalink

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  • In Drosophila, the compound eye photoreceptors and the H-B eyelet, a specialized photoreceptive structure located between the retina and the optic lobes, contain Rhodopsin photopigments, which activate the canonical invertebrate phototransduction cascade after being excited by light. We show that 2 of the photopigments present in these photoreceptors, Rhodopsin 5 (Rh5) and Rhodopsin 6 (Rh6), contribute to light synchronization in a mutant (norpAP41) that disrupts canonical phototransduction due to the absence of Phospholipase C-β(PLC-β). We reveal that norpAP41 is a true loss-of-function allele, resulting in a truncated PLC-βprotein that lacks the catalytic domain. Light reception mediated by Rh5 and Rh6 must therefore utilize either a different (nonretinal) PLC-βenzyme or alternative signaling mechanisms, at least in terms of clockrelevant photoreception.
  • In Drosophila, the compound eye photoreceptors and the H-B eyelet, a specialized photoreceptive structure located between the retina and the optic lobes, contain Rhodopsin photopigments, which activate the canonical invertebrate phototransduction cascade after being excited by light. We show that 2 of the photopigments present in these photoreceptors, Rhodopsin 5 (Rh5) and Rhodopsin 6 (Rh6), contribute to light synchronization in a mutant (norpAP41) that disrupts canonical phototransduction due to the absence of Phospholipase C-β(PLC-β). We reveal that norpAP41 is a true loss-of-function allele, resulting in a truncated PLC-βprotein that lacks the catalytic domain. Light reception mediated by Rh5 and Rh6 must therefore utilize either a different (nonretinal) PLC-βenzyme or alternative signaling mechanisms, at least in terms of clockrelevant photoreception. (en)
Title
  • Rhodpsin 5- and Rhodopsin 6-mediated clock synchronization in Drosophila melanogaster in independent of retinal phospholipase C-beta signaling
  • Rhodpsin 5- and Rhodopsin 6-mediated clock synchronization in Drosophila melanogaster in independent of retinal phospholipase C-beta signaling (en)
skos:prefLabel
  • Rhodpsin 5- and Rhodopsin 6-mediated clock synchronization in Drosophila melanogaster in independent of retinal phospholipase C-beta signaling
  • Rhodpsin 5- and Rhodopsin 6-mediated clock synchronization in Drosophila melanogaster in independent of retinal phospholipase C-beta signaling (en)
skos:notation
  • RIV/60077344:_____/12:00390649!RIV13-AV0-60077344
http://linked.open...avai/predkladatel
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  • I
http://linked.open...iv/cisloPeriodika
  • 1
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  • 165553
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  • RIV/60077344:_____/12:00390649
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  • Rhodopsin 5; Rhodopsin 6; phospholipase (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [C366CBB5000A]
http://linked.open...i/riv/nazevZdroje
  • Journal of Biological Rhythms
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  • 27
http://linked.open...iv/tvurceVysledku
  • Sehadová, Hana
  • Stanewsky, R.
  • Britt, S. G.
  • Chou, W.-H.
  • Gentile, C.
  • Szabo, G.
  • Szular, J.
http://linked.open...ain/vavai/riv/wos
  • 000299848100003
issn
  • 0748-7304
number of pages
http://bibframe.org/vocab/doi
  • 10.1177/0748730411431673
is http://linked.open...avai/riv/vysledek of
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