About: Effects of high tidal volume mechanical ventilation on production of cytokines, iNOS, and MIP-1 beta proteins in pigs

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About: Effects of high tidal volume mechanical ventilation on production of cytokines, iNOS, and MIP-1 beta proteins in pigs Goto Sponge Distinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.3109/01902148.2012.737404
Description	The aim of this study was to investigate longitudinal changes of the pulmonary inflammatory process as a result of mechanical stress due to mechanical ventilation. The concentrations of IL-8, TNF-alpha, MIP-1 beta, nitrites/nitrates, and inducible nitric oxide synthases (iNOS) were investigated indicate in bronchoalveolar lavage (BAL). Twenty-three piglets were divided into three groups. Group I: animals breathing spontaneously; group II: mechanical ventilation (tidal volume (TV) = 7 mL/kg, PEEP = 5 cmH(2)O); group III: mechanical ventilation (TV = 15 mL/kg, PEEP = 0 cmH(2)0). Concentrations of BAL nitrites/nitrates from groups II and III increased during the first hour of mechanical ventilation (P = .03 and .02, respectively). The highest expression of iNOS was observed during the first hour in groups II and III. IL-8 concentration increased significantly in groups II and III. Production of TNF-alpha increased significantly in group III during the second and third hour (P = .01). Concentration of MIP-1 beta was significantly increased in groups II and III after the first hour (P = .012 and P = .008, respectively). The aim of this study was to investigate longitudinal changes of the pulmonary inflammatory process as a result of mechanical stress due to mechanical ventilation. The concentrations of IL-8, TNF-alpha, MIP-1 beta, nitrites/nitrates, and inducible nitric oxide synthases (iNOS) were investigated indicate in bronchoalveolar lavage (BAL). Twenty-three piglets were divided into three groups. Group I: animals breathing spontaneously; group II: mechanical ventilation (tidal volume (TV) = 7 mL/kg, PEEP = 5 cmH(2)O); group III: mechanical ventilation (TV = 15 mL/kg, PEEP = 0 cmH(2)0). Concentrations of BAL nitrites/nitrates from groups II and III increased during the first hour of mechanical ventilation (P = .03 and .02, respectively). The highest expression of iNOS was observed during the first hour in groups II and III. IL-8 concentration increased significantly in groups II and III. Production of TNF-alpha increased significantly in group III during the second and third hour (P = .01). Concentration of MIP-1 beta was significantly increased in groups II and III after the first hour (P = .012 and P = .008, respectively). (en)
Title	Effects of high tidal volume mechanical ventilation on production of cytokines, iNOS, and MIP-1 beta proteins in pigs Effects of high tidal volume mechanical ventilation on production of cytokines, iNOS, and MIP-1 beta proteins in pigs (en)
skos:prefLabel	Effects of high tidal volume mechanical ventilation on production of cytokines, iNOS, and MIP-1 beta proteins in pigs Effects of high tidal volume mechanical ventilation on production of cytokines, iNOS, and MIP-1 beta proteins in pigs (en)
skos:notation	RIV/00669806:_____/13:10193024!RIV14-MZ0-00669806
http://linked.open...avai/predkladatel	Fakultní nemocnice Plzeň
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Kobr, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Plzeň
http://linked.open...dnocenehoVysledku	71951
http://linked.open...ai/riv/idVysledku	RIV/00669806:_____/13:10193024
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	TNF-alpha; pigs; MIP-1 beta protein; mechanical ventilation; iNOS (en)
http://linked.open.../riv/klicoveSlovo	MIP-1 beta protein iNOS pigs mechanical ventilation TNF-alpha
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[AFCD23EFCDD8]
http://linked.open...i/riv/nazevZdroje	Experimental Lung Research
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	39
http://linked.open...iv/tvurceVysledku	Kobr, Jiří Martásek, Pavel Mikula, Ivan Pokorná, Pavla Vobruba, Václav Černá, Olga Hřídel, Jan Brantová, Olga Klimenko, Oxana
http://linked.open...ain/vavai/riv/wos	000313682100001
issn	0190-2148
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.3109/01902148.2012.737404

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