About: Hyaluronan-cetyltrimethylammonium bromide interactions in aqueous and physiological solution studied by fluorescence techniques

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of this work was to study systems composed of negatively charged polyelectrolyte – hyaluronan and positively charged surfactant – cetyltrimethylammonium bromide (CTAB), which could be potential used for targeted drug delivery. Two concentration series was mixed – in an aqueous solution and in 0.15 mol l-1 sodium chloride (simply physiological solution). In the series, the concentration of hyaluronan was constant and the concentration of CTAB (well below the critical micelle concentration in water solution) was increased. The interactions between these components were studied in terms of the formation of hydrophobic domains, which were important for solubilization of molecules of hydrophobic drugs. The intensity of fluorescence, steady-state anisotropy and lifetime of the samples were measured. Perylene was chosen as fluorescent probe due to its hydrophobicity. It was found that in aqueous solution, small hydrophobic domains linked to hyaluronan chains are formed. Then an increasing conc The aim of this work was to study systems composed of negatively charged polyelectrolyte – hyaluronan and positively charged surfactant – cetyltrimethylammonium bromide (CTAB), which could be potential used for targeted drug delivery. Two concentration series was mixed – in an aqueous solution and in 0.15 mol l-1 sodium chloride (simply physiological solution). In the series, the concentration of hyaluronan was constant and the concentration of CTAB (well below the critical micelle concentration in water solution) was increased. The interactions between these components were studied in terms of the formation of hydrophobic domains, which were important for solubilization of molecules of hydrophobic drugs. The intensity of fluorescence, steady-state anisotropy and lifetime of the samples were measured. Perylene was chosen as fluorescent probe due to its hydrophobicity. It was found that in aqueous solution, small hydrophobic domains linked to hyaluronan chains are formed. Then an increasing conc (en)
Title	Hyaluronan-cetyltrimethylammonium bromide interactions in aqueous and physiological solution studied by fluorescence techniques Hyaluronan-cetyltrimethylammonium bromide interactions in aqueous and physiological solution studied by fluorescence techniques (en)
skos:prefLabel	Hyaluronan-cetyltrimethylammonium bromide interactions in aqueous and physiological solution studied by fluorescence techniques Hyaluronan-cetyltrimethylammonium bromide interactions in aqueous and physiological solution studied by fluorescence techniques (en)
skos:notation	RIV/00216305:26310/14:PU113581!RIV15-MSM-26310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(LD12068)
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Mravec, Filip Pekař, Miloslav Holínková, Petra
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Fakulta chemická
http://linked.open...dnocenehoVysledku	20029
http://linked.open...ai/riv/idVysledku	RIV/00216305:26310/14:PU113581
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Fluorescence anisotropy, interaction, perylene, minimicelles, hydrophobic domains, CAC, critical aggregation concentration (en)
http://linked.open.../riv/klicoveSlovo	Fluorescence anisotropy interaction CAC perylene critical aggregation concentration hydrophobic domains minimicelles
http://linked.open...ontrolniKodProRIV	[2E08EE99C059]
http://linked.open...v/mistoKonaniAkce	Purkyňova 118, 612 00 Brno
http://linked.open...i/riv/mistoVydani	Brno
http://linked.open...i/riv/nazevZdroje	Chemie je život 2014 - Sborník příspěvků
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Preparation of hyaluronan-micellar-aggregate colloids for nanomedical applications and characterization of their properties
http://linked.open...UplatneniVysledku	2014
http://linked.open...iv/tvurceVysledku	Mravec, Filip Pekař, Miloslav Holínková, Petra
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2014-12-04 (xsd:date)
number of pages	6 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Neuveden
https://schema.org/isbn	978-80-214-5078-3
http://localhost/t...ganizacniJednotka	26310

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