About: Sensitive voltammetric method for determination of chemotherapeutic drug methotrexate using liquid mercury free silver solid amalgam electrode

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Voltammetric behavior of a wide-spread used chemotherapeutic drug methotrexate (MTX) has been investigated on a polished silver solid amalgam electrode (p-AgSAE) employing various voltammetric methods like cyclic voltammetry, direct current voltammetry and differential pulse voltammetry. It was found that MTX provided two reduction and one oxidation peak in an acidic medium and the positively situated reduction signal (Ep = -340 mV), due its favorable analytical properties, was studied more in detail. 0.05 mol L-1 acetate buffer of pH 5 was selected as an optimal medium for monitoring of the MTX reduction on p-AgSAE. Operating parameters of differential pulse voltammetry were optimized and proposed voltammetric method provided high repeatability (relative standard deviation of 11 repeated measurements at concentration level of methotrexate of 1x10-7 mol L-1 equaled to 1.7%), linear concentration range from 5x10-10 to 3x10-6 mol L-1 and low limit of detection (LD = 1.5x10-10 mol L-1). The applicability of proposed method was verified by analysis of real sample of chemotherapeutic preparation. Voltammetric behavior of a wide-spread used chemotherapeutic drug methotrexate (MTX) has been investigated on a polished silver solid amalgam electrode (p-AgSAE) employing various voltammetric methods like cyclic voltammetry, direct current voltammetry and differential pulse voltammetry. It was found that MTX provided two reduction and one oxidation peak in an acidic medium and the positively situated reduction signal (Ep = -340 mV), due its favorable analytical properties, was studied more in detail. 0.05 mol L-1 acetate buffer of pH 5 was selected as an optimal medium for monitoring of the MTX reduction on p-AgSAE. Operating parameters of differential pulse voltammetry were optimized and proposed voltammetric method provided high repeatability (relative standard deviation of 11 repeated measurements at concentration level of methotrexate of 1x10-7 mol L-1 equaled to 1.7%), linear concentration range from 5x10-10 to 3x10-6 mol L-1 and low limit of detection (LD = 1.5x10-10 mol L-1). The applicability of proposed method was verified by analysis of real sample of chemotherapeutic preparation. (en)
Title	Sensitive voltammetric method for determination of chemotherapeutic drug methotrexate using liquid mercury free silver solid amalgam electrode Sensitive voltammetric method for determination of chemotherapeutic drug methotrexate using liquid mercury free silver solid amalgam electrode (en)
skos:prefLabel	Sensitive voltammetric method for determination of chemotherapeutic drug methotrexate using liquid mercury free silver solid amalgam electrode Sensitive voltammetric method for determination of chemotherapeutic drug methotrexate using liquid mercury free silver solid amalgam electrode (en)
skos:notation	RIV/00216275:25310/14:39898015!RIV15-MSM-25310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(EE2.3.30.0021)
http://linked.open...iv/cisloPeriodika	září 2014
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Šelešovská, Renáta Chýlková, J. Bandžuchová, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Pardubice / Fakulta chemicko-technologická
http://linked.open...dnocenehoVysledku	44448
http://linked.open...ai/riv/idVysledku	RIV/00216275:25310/14:39898015
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	determination; silver solid amalgam electrode; voltammetry; methotrexate (en)
http://linked.open.../riv/klicoveSlovo	silver solid amalgam electrode voltammetry determination methotrexate
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[1000A5DE799C]
http://linked.open...i/riv/nazevZdroje	Scientific Papers of the University of Pardubice, Series A, Faculty of Chemical Technology
http://linked.open...in/vavai/riv/obor	CG
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Strenthening of Research and Development Teams at the University of Pardubice
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Chýlková, Jaromíra Šelešovská, Renáta Bandžuchová, Lenka
issn	1211-5541
number of pages	16 (xsd:int)
http://localhost/t...ganizacniJednotka	25310

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