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  • The pH-rate profile of the pseudo-first-order rate constants for the rearrangement and hydrolysis of Ezetimibe giving (2R,3R,6S)-N,6-bis(4-fluorophenyl)-2-(4-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-3-carboxamide (2) as the main product at pH of less than 12.5 and the mixture of 2 and 5-(4-fluorophenyl)-5-hydroxy-2-[(4-fluorophenylamino)-(4-hydroxyphenyl)methyl]-pentanoic acid (3) at pH of more than 12.5 in aqueous tertiary amine buffers and in sodium hydroxide solutions at ionic strength I = 0.1 mol L-1 (KCl) and at 39 degrees C is reported.
  • The pH-rate profile of the pseudo-first-order rate constants for the rearrangement and hydrolysis of Ezetimibe giving (2R,3R,6S)-N,6-bis(4-fluorophenyl)-2-(4-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-3-carboxamide (2) as the main product at pH of less than 12.5 and the mixture of 2 and 5-(4-fluorophenyl)-5-hydroxy-2-[(4-fluorophenylamino)-(4-hydroxyphenyl)methyl]-pentanoic acid (3) at pH of more than 12.5 in aqueous tertiary amine buffers and in sodium hydroxide solutions at ionic strength I = 0.1 mol L-1 (KCl) and at 39 degrees C is reported. (en)
Title
  • Kinetics and Mechanism of the Base-Catalyzed Rearrangement and Hydrolysis of Ezetimibe
  • Kinetics and Mechanism of the Base-Catalyzed Rearrangement and Hydrolysis of Ezetimibe (en)
skos:prefLabel
  • Kinetics and Mechanism of the Base-Catalyzed Rearrangement and Hydrolysis of Ezetimibe
  • Kinetics and Mechanism of the Base-Catalyzed Rearrangement and Hydrolysis of Ezetimibe (en)
skos:notation
  • RIV/00216275:25310/14:39897721!RIV15-MSM-25310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, S
http://linked.open...iv/cisloPeriodika
  • 8
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 24246
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  • RIV/00216275:25310/14:39897721
http://linked.open...riv/jazykVysledku
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  • Ezetimibe.; Hydrolysis; Rearrangement; Catalysis; Mechanism; Kinetics (en)
http://linked.open.../riv/klicoveSlovo
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  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [0037FB5B22FC]
http://linked.open...i/riv/nazevZdroje
  • Journal of Pharmaceutical Science
http://linked.open...in/vavai/riv/obor
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 103
http://linked.open...iv/tvurceVysledku
  • Imramovský, Aleš
  • Hájíček, Josef
  • Hanusek, Jiří
  • Baťová, Jana
  • Hejtmánková, Ludmila
http://linked.open...ain/vavai/riv/wos
  • 000340277700003
issn
  • 0022-3549
number of pages
http://bibframe.org/vocab/doi
  • 10.1002/jps.24070
http://localhost/t...ganizacniJednotka
  • 25310
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