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  • Alzheimer disease (AD) is the most prevalent cause of dementia in the elderly population today with an increasing tendency. In spite of the fact that it is so common, AD often goes unrecognized or is misdiagnosed in its early stages. The importance of the early and accurate diagnosis is evident. Development of valuable diagnostic methods for determination of AD specific biomarkers, such as Abeta peptides and Tau protein, is one of the current goals. The aim of this study is integration of immunomagnetic carrier with orientedly immobilized anti-Aβ antibody into microfluidic device and an application of this system for immunoprecipitation of Abeta peptides. Binding efficiency and specificity of the immunosorbent were validated by serum or cerebrospinal fluid spiked with synthetic Abeta peptides.
  • Alzheimer disease (AD) is the most prevalent cause of dementia in the elderly population today with an increasing tendency. In spite of the fact that it is so common, AD often goes unrecognized or is misdiagnosed in its early stages. The importance of the early and accurate diagnosis is evident. Development of valuable diagnostic methods for determination of AD specific biomarkers, such as Abeta peptides and Tau protein, is one of the current goals. The aim of this study is integration of immunomagnetic carrier with orientedly immobilized anti-Aβ antibody into microfluidic device and an application of this system for immunoprecipitation of Abeta peptides. Binding efficiency and specificity of the immunosorbent were validated by serum or cerebrospinal fluid spiked with synthetic Abeta peptides. (en)
Title
  • Microfluidic system with integrated magnetic carrier for immunoprecipitation of Abeta peptides
  • Microfluidic system with integrated magnetic carrier for immunoprecipitation of Abeta peptides (en)
skos:prefLabel
  • Microfluidic system with integrated magnetic carrier for immunoprecipitation of Abeta peptides
  • Microfluidic system with integrated magnetic carrier for immunoprecipitation of Abeta peptides (en)
skos:notation
  • RIV/00216275:25310/09:00008575!RIV10-MSM-25310___
http://linked.open...avai/riv/aktivita
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  • R
http://linked.open...vai/riv/dodaniDat
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  • 326180
http://linked.open...ai/riv/idVysledku
  • RIV/00216275:25310/09:00008575
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Alzheimer disease; Abeta peptides; immunoprecipitation; microfluidic system (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [83DE8A18FECF]
http://linked.open...v/mistoKonaniAkce
  • Praha
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  • Pianoro
http://linked.open...i/riv/nazevZdroje
  • New Trends in Alzheimer and Parkinson Related Disorders: ADPD 2009
http://linked.open...in/vavai/riv/obor
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http://linked.open...UplatneniVysledku
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  • Hernychová, Lenka
  • Bílková, Zuzana
  • Jankovičová, Barbora
  • Viovy, Jean-Louis
  • Slováková, Marcela
  • Zvěřinová, Zuzana
  • Faigle, Wolfgang
  • Mohamadi, Reza
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
number of pages
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  • MEDIMOND s.r.l.
https://schema.org/isbn
  • 978-88-7587-528-2
http://localhost/t...ganizacniJednotka
  • 25310
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