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rdf:type
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Description
| - Glioblastoma multiforme (GBM) is the most frequent primary malignant brain tumor with very poor prognosis. Despite an optimal treatment composed of a maximal surgical resection followed an intense concomitant chemoradiotherapy with temozolomide and adjuvant temozolomide, the median of overall survival remains only 12-15 months from diagnosis. Because of a different response to treatment, it is very important to find new biomarkers that can be used in prediction of a clinical outcome in GBM patients, who underwent chemoradiotherapy. MicroRNAs are highly conserved, small, non-coding RNAs that function as post-transcriptional regulators of gene expression. Therefore, these molecules play key role in pathogenesis of many cancers, including GBM.
- Glioblastoma multiforme (GBM) is the most frequent primary malignant brain tumor with very poor prognosis. Despite an optimal treatment composed of a maximal surgical resection followed an intense concomitant chemoradiotherapy with temozolomide and adjuvant temozolomide, the median of overall survival remains only 12-15 months from diagnosis. Because of a different response to treatment, it is very important to find new biomarkers that can be used in prediction of a clinical outcome in GBM patients, who underwent chemoradiotherapy. MicroRNAs are highly conserved, small, non-coding RNAs that function as post-transcriptional regulators of gene expression. Therefore, these molecules play key role in pathogenesis of many cancers, including GBM. (en)
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Title
| - Expression analysis of microRNAs in relation to the chemoradioresistance of glioblastoma
- Expression analysis of microRNAs in relation to the chemoradioresistance of glioblastoma (en)
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skos:prefLabel
| - Expression analysis of microRNAs in relation to the chemoradioresistance of glioblastoma
- Expression analysis of microRNAs in relation to the chemoradioresistance of glioblastoma (en)
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skos:notation
| - RIV/00216224:14740/13:00065596!RIV14-MZ0-14740___
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http://linked.open...avai/predkladatel
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(ED1.1.00/02.0068), P(NT13514)
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14740/13:00065596
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - microRNA; chemoresistance; radioresistance; glioblastoma multiforme (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Slabý, Ondřej
- Šána, Jiří
- Lakomý, Radek
- Smrčka, Martin
- Vyzula, Rostislav
- Bešše, Andrej
- Kosařová, Zdeňka
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http://localhost/t...ganizacniJednotka
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