About: Kinetic Study of Metal Complexes with Tetraazamacrocyclic Ligands with Carboxylate/Phosphonate Pendant Arms

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Ln(III) and Cu(II) complexes are utilized in medicine and preclinical research as magnetic resonance, optical or nuclear probes for diagnostics and/or for cancer treatment. For biomedical applications, such complexes should exhibit a high thermodynamic stability as well as kinetic inertness under physiological conditions. Thus, knowledge of their thermodynamic/kinetic properties (e.g. dissociation rate constants for an estimation of kinetic inertness) is important to evaluate their use in these applications. Here, thermodynamic and kinetic properties of Cu(II), Ce(III) and Eu(III) complexes with macrocyclic cyclen-based ligands where acetate pendant arms were substituted by phosphonates (H4dota, H5do3ap, trans-H6do2a2p, H7doa3p, H8dotp) [1–4] are presented. In addition, the influence of substitution of one acetate/phosphonate of (H2do2a/H3do3a/H4dota/H5do3ap derivatives) and/or all phosphonate pendant arms (H8dotp derivatives) was also studied [5-7]. Ln(III) and Cu(II) complexes are utilized in medicine and preclinical research as magnetic resonance, optical or nuclear probes for diagnostics and/or for cancer treatment. For biomedical applications, such complexes should exhibit a high thermodynamic stability as well as kinetic inertness under physiological conditions. Thus, knowledge of their thermodynamic/kinetic properties (e.g. dissociation rate constants for an estimation of kinetic inertness) is important to evaluate their use in these applications. Here, thermodynamic and kinetic properties of Cu(II), Ce(III) and Eu(III) complexes with macrocyclic cyclen-based ligands where acetate pendant arms were substituted by phosphonates (H4dota, H5do3ap, trans-H6do2a2p, H7doa3p, H8dotp) [1–4] are presented. In addition, the influence of substitution of one acetate/phosphonate of (H2do2a/H3do3a/H4dota/H5do3ap derivatives) and/or all phosphonate pendant arms (H8dotp derivatives) was also studied [5-7]. (en)
Title	Kinetic Study of Metal Complexes with Tetraazamacrocyclic Ligands with Carboxylate/Phosphonate Pendant Arms Kinetic Study of Metal Complexes with Tetraazamacrocyclic Ligands with Carboxylate/Phosphonate Pendant Arms (en)
skos:prefLabel	Kinetic Study of Metal Complexes with Tetraazamacrocyclic Ligands with Carboxylate/Phosphonate Pendant Arms Kinetic Study of Metal Complexes with Tetraazamacrocyclic Ligands with Carboxylate/Phosphonate Pendant Arms (en)
skos:notation	RIV/00216224:14740/12:00062140!RIV13-MSM-14740___
http://linked.open...avai/predkladatel	Středoevropský technologický institut
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068), P(ME09065), S
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Lubal, Přemysl
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	144653
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/12:00062140
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	macrocyclic ligands; metal complexes; kinetics (en)
http://linked.open.../riv/klicoveSlovo	kinetics metal complexes macrocyclic ligands
http://linked.open...ontrolniKodProRIV	[AC53FEF64EC1]
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology Research of new detection systems based on sensor arrays for application in speciation analysis
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Hermann, Petr Kotek, Jan Lubal, Přemysl Campello, M.P.C. Santos, I.
http://localhost/t...ganizacniJednotka	14740

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