About: Cognitive effects of long-term treatment with waking-hour subcutaneous apomorphine infusions in patients with advanced Parkinson's disease

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.csnn.eu/en/czech-slovak-neurology-article/cognitive-effects-of-long-term-treatment-with-waking-hour-subcutaneous-apomorphine-infusions-in-patients-with-adv-35795?confirm_rules=1
Description	Aims: To determine whether long-term treatment with continuous subcutaneous apomorphine infusions (CSAI) is safe for patients with Parkinson's disease (PD) with a history of hallucinations and/or marked cognitive deficit. Methods: 12 PD patients (9 men, 3 women; age 71.8 +- 6 years) were given neuropsychological assessment prior to continuous administration of CSAI and fourteen months after it. Results: CSAI led to clinical improvement, at least minimal, in all subjects. However, the treatment led to statistically significant impairment in verbal fluency tasks, the Mattis dementia rating scale (MDRS) score and the attention and initiation subtests. No mood changes were detected. Conclusions: We observed significant impairment in %22frontal-like%22 tasks after continuous treatment with CSAI in our PD patients with baseline cognitive impairment. Further longitudinal controlled studies are needed to assess the impact of both CSAI and PD progression. Aims: To determine whether long-term treatment with continuous subcutaneous apomorphine infusions (CSAI) is safe for patients with Parkinson's disease (PD) with a history of hallucinations and/or marked cognitive deficit. Methods: 12 PD patients (9 men, 3 women; age 71.8 +- 6 years) were given neuropsychological assessment prior to continuous administration of CSAI and fourteen months after it. Results: CSAI led to clinical improvement, at least minimal, in all subjects. However, the treatment led to statistically significant impairment in verbal fluency tasks, the Mattis dementia rating scale (MDRS) score and the attention and initiation subtests. No mood changes were detected. Conclusions: We observed significant impairment in %22frontal-like%22 tasks after continuous treatment with CSAI in our PD patients with baseline cognitive impairment. Further longitudinal controlled studies are needed to assess the impact of both CSAI and PD progression. (en)
Title	Cognitive effects of long-term treatment with waking-hour subcutaneous apomorphine infusions in patients with advanced Parkinson's disease Cognitive effects of long-term treatment with waking-hour subcutaneous apomorphine infusions in patients with advanced Parkinson's disease (en)
skos:prefLabel	Cognitive effects of long-term treatment with waking-hour subcutaneous apomorphine infusions in patients with advanced Parkinson's disease Cognitive effects of long-term treatment with waking-hour subcutaneous apomorphine infusions in patients with advanced Parkinson's disease (en)
skos:notation	RIV/00216224:14740/11:00060542!RIV13-MSM-14740___
http://linked.open...avai/predkladatel	Středoevropský technologický institut
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068), Z(MSM0021622404)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Tyrlík, Mojmír Rektorová, Irena Kubíková, Radka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	190790
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/11:00060542
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Affective; Apomorphine; Cognitive; Dementia; Parkinson's disease (en)
http://linked.open.../riv/klicoveSlovo	Affective Apomorphine Cognitive Dementia Parkinson's disease
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[EA677F17F4FE]
http://linked.open...i/riv/nazevZdroje	Ceska a Slovenska Neurologie a Neurochirurgie
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	74
http://linked.open...iv/tvurceVysledku	Kubíková, Radka Rektorová, Irena Tyrlík, Mojmír
http://linked.open...ain/vavai/riv/wos	000294035900009
http://linked.open...n/vavai/riv/zamer	The Internal Organisation and Neurobiological Mechanisms of Functional CNS Systems under Normal and Pathological Conditions
issn	1210-7859
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	14740
is http://linked.open...avai/riv/vysledek of	Cognitive effects of long-term treatment with waking-hour subcutaneous apomorphine infusions in patients with advanced Parkinson's disease

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