About: Postreceptor effect of antidepressants on C6 glioma cells and NK lymphocytes

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We studied antidepressant (AD) evoked cell signalling alterations in relationship to heterotrimeric GTP-binding (G) proteins, effector phospholipase C (PLC) and apoptosis. We used rat C6 glioma cell line, C6 glioma cells transfected (t) with pig thymus lymphocyte markers (MHCII, CD4 etc.)and natural killer (NK) lymphocytes. We analysed postreceptor effects of fluoxetine, FLU and sertraline, SER, specific serotonin reuptake inhibitors (SSR1). We estimated acute effects (20-24 h) and AD on Galfa subunits using ELISA and western immunoblotting with our antibodies. We demonstrated FLU effect on decreased level of Galfa q/11 in both C6 glioma and NK cells, in contrast to FLU induced changes of Galfas and Galfa(i1,2) in (t)C6 glioma cells. In C6 glioma cells, FLU induced Galga q/11 subunit translocation from membrane into cytosol and lower IP3 level, second messenger released by PLC and subsequent apoptotic events were observed. On the other hand SER effects on C6 glioma cells were linked to Galfys mainly w We studied antidepressant (AD) evoked cell signalling alterations in relationship to heterotrimeric GTP-binding (G) proteins, effector phospholipase C (PLC) and apoptosis. We used rat C6 glioma cell line, C6 glioma cells transfected (t) with pig thymus lymphocyte markers (MHCII, CD4 etc.)and natural killer (NK) lymphocytes. We analysed postreceptor effects of fluoxetine, FLU and sertraline, SER, specific serotonin reuptake inhibitors (SSR1). We estimated acute effects (20-24 h) and AD on Galfa subunits using ELISA and western immunoblotting with our antibodies. We demonstrated FLU effect on decreased level of Galfa q/11 in both C6 glioma and NK cells, in contrast to FLU induced changes of Galfas and Galfa(i1,2) in (t)C6 glioma cells. In C6 glioma cells, FLU induced Galga q/11 subunit translocation from membrane into cytosol and lower IP3 level, second messenger released by PLC and subsequent apoptotic events were observed. On the other hand SER effects on C6 glioma cells were linked to Galfys mainly w (en)
Title	Postreceptor effect of antidepressants on C6 glioma cells and NK lymphocytes Postreceptor effect of antidepressants on C6 glioma cells and NK lymphocytes (en)
skos:prefLabel	Postreceptor effect of antidepressants on C6 glioma cells and NK lymphocytes Postreceptor effect of antidepressants on C6 glioma cells and NK lymphocytes (en)
skos:notation	RIV/00216224:14310/99:00004115!RIV/2002/GA0/143102/N
http://linked.open.../vavai/riv/strany	87
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA310/98/0347), Z(MSM 161700001)
http://linked.open...iv/cisloPeriodika	48
http://linked.open...vai/riv/dodaniDat	2002
http://linked.open...aciTvurceVysledku	Španová, Alena Matalová, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	750204
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/99:00004115
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Postreceptor effect of antidepressants on C6 glioma cells and NK lymphocytes (en)
http://linked.open.../riv/klicoveSlovo	Postreceptor effect of antidepressants on C6 glioma cells and NK lymphocytes
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[A4709C89AD29]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	The dopamine and prolactin role during tumor progression and immunomodulatory effect of dopaminergic ergot alkaloids.
http://linked.open...UplatneniVysledku	1999
http://linked.open...v/svazekPeriodika	1999
http://linked.open...iv/tvurceVysledku	Lisá, Věra Španová, Alena Fišerová, Anna Matalová, Eva Kovářů, Hana
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20161700001
issn	0862-8408
number of pages	1 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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