About: LC-MS/MS determination of potential endocrine disruptors of cortico signalling in rivers and wastewaters

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About: LC-MS/MS determination of potential endocrine disruptors of cortico signalling in rivers and wastewaters Goto Sponge Distinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://link.springer.com/article/10.1007%2Fs00216-014-8206-9
Description	A targeted analytical method was established to determine a large number of chemicals known to interfere with the gluco- and mineralocorticoid signalling pathway. The analytes comprise 30 glucocorticoids and 9 mineralocorticoids. Ten out of these corticosteroids were primary metabolites. Additionally, 14 nonsteroids were included. These analytes represent a broader range of possible adverse modes of action than previously reported. For the simultaneous determination of these structurally diverse compounds, a single-step multimode solid-phase extraction and pre-concentration was applied. Extracts were separated by a short linear HPLC gradient (20 min) on a core shell RP column (2.7 mu m particle size) and compounds identified and quantified by LC-MS/MS. The method provided excellent retention time reproducibility and detection limits in the low nanograms per litre range. A targeted analytical method was established to determine a large number of chemicals known to interfere with the gluco- and mineralocorticoid signalling pathway. The analytes comprise 30 glucocorticoids and 9 mineralocorticoids. Ten out of these corticosteroids were primary metabolites. Additionally, 14 nonsteroids were included. These analytes represent a broader range of possible adverse modes of action than previously reported. For the simultaneous determination of these structurally diverse compounds, a single-step multimode solid-phase extraction and pre-concentration was applied. Extracts were separated by a short linear HPLC gradient (20 min) on a core shell RP column (2.7 mu m particle size) and compounds identified and quantified by LC-MS/MS. The method provided excellent retention time reproducibility and detection limits in the low nanograms per litre range. (en)
Title	LC-MS/MS determination of potential endocrine disruptors of cortico signalling in rivers and wastewaters LC-MS/MS determination of potential endocrine disruptors of cortico signalling in rivers and wastewaters (en)
skos:prefLabel	LC-MS/MS determination of potential endocrine disruptors of cortico signalling in rivers and wastewaters LC-MS/MS determination of potential endocrine disruptors of cortico signalling in rivers and wastewaters (en)
skos:notation	RIV/00216224:14310/14:00079393!RIV15-MSM-14310___
http://linked.open...avai/riv/aktivita	I S
http://linked.open...avai/riv/aktivity	I, S
http://linked.open...iv/cisloPeriodika	29
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Macíková, Petra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	25798
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/14:00079393
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Environmental endocrine disruptors; Corticosteroid signalling pathway; Pharmaceuticals; Metabolites; Surface water (en)
http://linked.open.../riv/klicoveSlovo	Corticosteroid signalling pathway Environmental endocrine disruptors Metabolites Pharmaceuticals Surface water
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[5E43DD66F616]
http://linked.open...i/riv/nazevZdroje	Analytical and Bioanalytical chemistry
http://linked.open...in/vavai/riv/obor	DJ
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	406
http://linked.open...iv/tvurceVysledku	Macíková, Petra Schirmer, Kristin Ammann, Adrian A. Groh, Ksenia J. Suter, Marc J.F.
http://linked.open...ain/vavai/riv/wos	000344860300024
issn	1618-2642
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s00216-014-8206-9
http://localhost/t...ganizacniJednotka	14310

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