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  • Apicomplexans represent one of the most successful and diverse group of unicellular parasites exhibiting unique adaptations to their life style. Many of them are causative agents for major human diseases (such as malaria, toxoplasmosis and cryptosporidiosis), which are still poorly controlled and require development of novel sustainable therapies. The apicomplexan cytoskeletal elements play an important role in various life processes and thus they represent a potential target for chemotherapeutic intervention. Their highly motile invasive zoites use a unique conserved form of actin-based gliding motility for movement, host cell invasion and tissue traversal. Our intent is to investigate if the glideosome concept, proposed in Toxoplasma, could be also applied to basal lineages of Apicomplexa. We focus on deep-branching groups, especially gregarines and protococcidians, restricted to invertebrates (Diakin et al. 2012).
  • Apicomplexans represent one of the most successful and diverse group of unicellular parasites exhibiting unique adaptations to their life style. Many of them are causative agents for major human diseases (such as malaria, toxoplasmosis and cryptosporidiosis), which are still poorly controlled and require development of novel sustainable therapies. The apicomplexan cytoskeletal elements play an important role in various life processes and thus they represent a potential target for chemotherapeutic intervention. Their highly motile invasive zoites use a unique conserved form of actin-based gliding motility for movement, host cell invasion and tissue traversal. Our intent is to investigate if the glideosome concept, proposed in Toxoplasma, could be also applied to basal lineages of Apicomplexa. We focus on deep-branching groups, especially gregarines and protococcidians, restricted to invertebrates (Diakin et al. 2012). (en)
Title
  • Cell motility in marine early emerging apicomplexans
  • Cell motility in marine early emerging apicomplexans (en)
skos:prefLabel
  • Cell motility in marine early emerging apicomplexans
  • Cell motility in marine early emerging apicomplexans (en)
skos:notation
  • RIV/00216224:14310/12:00058218!RIV13-GA0-14310___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
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  • P(GBP505/12/G112)
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  • 126224
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  • RIV/00216224:14310/12:00058218
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  • apicomplexa; gregarines; cell motility; cortex; pellicle; actin; myosin; marine (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [70B1B4F6D8EF]
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http://linked.open...iv/tvurceVysledku
  • Valigurová, Andrea
  • Diakin, Andrei
  • Schrevel, Joseph
  • Simdyanov, Timur G.
http://localhost/t...ganizacniJednotka
  • 14310
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