About: Amplification of hTERC (3q26) and MYCC (8q24) genes in correlation with oncogenic human papilloma virus infection in cervical cancer

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About: Amplification of hTERC (3q26) and MYCC (8q24) genes in correlation with oncogenic human papilloma virus infection in cervical cancer Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cervical cancer remains one of the most common malignancies among women worldwide in both incidence and mortality. Several premalignant stages can be distinguished in the development of invasive carcinoma, including cervical intraepithelial neoplasia grades I-III (CIN I–III). The genetic basis of progression of CIN I to CIN II/III and to invasive carcinoma remain poorly understood. Although infection of high-risk human papilloma virus (HPV) is recognized as an essential initiating event in cervical tumorigenesis, this alone is not sufficient for the progression to invasive cancer. Some chromosomal aberrations have been associated with the progression of CIN to carcinoma, especially the amplification of the human telomerase gene hTERC (3q26) and protooncogene MYCC (8q24). Cervical cancer remains one of the most common malignancies among women worldwide in both incidence and mortality. Several premalignant stages can be distinguished in the development of invasive carcinoma, including cervical intraepithelial neoplasia grades I-III (CIN I–III). The genetic basis of progression of CIN I to CIN II/III and to invasive carcinoma remain poorly understood. Although infection of high-risk human papilloma virus (HPV) is recognized as an essential initiating event in cervical tumorigenesis, this alone is not sufficient for the progression to invasive cancer. Some chromosomal aberrations have been associated with the progression of CIN to carcinoma, especially the amplification of the human telomerase gene hTERC (3q26) and protooncogene MYCC (8q24). (en)
Title	Amplification of hTERC (3q26) and MYCC (8q24) genes in correlation with oncogenic human papilloma virus infection in cervical cancer Amplification of hTERC (3q26) and MYCC (8q24) genes in correlation with oncogenic human papilloma virus infection in cervical cancer (en)
skos:prefLabel	Amplification of hTERC (3q26) and MYCC (8q24) genes in correlation with oncogenic human papilloma virus infection in cervical cancer Amplification of hTERC (3q26) and MYCC (8q24) genes in correlation with oncogenic human papilloma virus infection in cervical cancer (en)
skos:notation	RIV/00216224:14310/11:00055260!RIV12-MSM-14310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Mouková, Lucie Kuglík, Petr Slámová, Iva Kiššová, Miroslava
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	185379
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/11:00055260
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cervix uteri; hTERC; MYCC; FISH; papiloma virus (en)
http://linked.open.../riv/klicoveSlovo	FISH MYCC cervix uteri hTERC papiloma virus
http://linked.open...ontrolniKodProRIV	[7193AF1D2271]
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...iv/tvurceVysledku	Kiššová, Miroslava Kuglík, Petr Mouková, Lucie Slámová, Iva Vranová, Vladimíra
http://localhost/t...ganizacniJednotka	14310

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