About: Conformational Analysis of Complex Oligosaccharides: The CICADA Approach to the Uromodulin O-Glycans     Goto   Sponge   Distinct   Permalink

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Description
  • Konformační analýza složitých oligosacharidů (cs)
  • Uromodulin is the pregancy associated Tamm-Horsfall glycoprotein, with ability to inhibit T-cell proliferation. Pregnancy-associated structural changes mainly occur in the O-glycosylation of this glycoprotein. These include up to 12 glycan structures, made up of an unusual core type 2 sequence terminated with one, two, or three sialyl Lewisx sequences; they could serve as E- and P-selectin ligands. The present work focuses on the most complex one; a tetradecamer made up of a type 2 core carrying three sialyl Lewisx branches. Five monosaccharides are assembled by fourteen glycosidic linkages. The conformational behaviour of the constituting disaccharide segments was evaluated using the flexible residue procedure of the MM3 molecular mechanics procedure. For each disaccharide, the adiabatic energy surface, along with the local energy minima have been established. All these results were used for the generation, prior to complete optimization of the tetradecamer. This was followed by a complete exploratio
  • Uromodulin is the pregancy associated Tamm-Horsfall glycoprotein, with ability to inhibit T-cell proliferation. Pregnancy-associated structural changes mainly occur in the O-glycosylation of this glycoprotein. These include up to 12 glycan structures, made up of an unusual core type 2 sequence terminated with one, two, or three sialyl Lewisx sequences; they could serve as E- and P-selectin ligands. The present work focuses on the most complex one; a tetradecamer made up of a type 2 core carrying three sialyl Lewisx branches. Five monosaccharides are assembled by fourteen glycosidic linkages. The conformational behaviour of the constituting disaccharide segments was evaluated using the flexible residue procedure of the MM3 molecular mechanics procedure. For each disaccharide, the adiabatic energy surface, along with the local energy minima have been established. All these results were used for the generation, prior to complete optimization of the tetradecamer. This was followed by a complete exploratio (en)
Title
  • Conformational Analysis of Complex Oligosaccharides: The CICADA Approach to the Uromodulin O-Glycans
  • Conformational Analysis of Complex Oligosaccharides: The CICADA Approach to the Uromodulin O-Glycans (en)
  • Konformační analýza složitých oligosacharidů (cs)
skos:prefLabel
  • Conformational Analysis of Complex Oligosaccharides: The CICADA Approach to the Uromodulin O-Glycans
  • Conformational Analysis of Complex Oligosaccharides: The CICADA Approach to the Uromodulin O-Glycans (en)
  • Konformační analýza složitých oligosacharidů (cs)
skos:notation
  • RIV/00216224:14310/04:00010477!RIV08-MSM-14310___
http://linked.open.../vavai/riv/strany
  • 949-959
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 143100005)
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 558596
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/04:00010477
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • conformational analysis; oligosaccharide; CICADA (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [8ADE1A144F52]
http://linked.open...i/riv/nazevZdroje
  • Carbohydrate Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 339
http://linked.open...iv/tvurceVysledku
  • Koča, Jaroslav
  • Perez, Serge
  • Rivet, Alain
  • Gianluca, Cioci
http://linked.open...n/vavai/riv/zamer
issn
  • 0008-6215
number of pages
http://localhost/t...ganizacniJednotka
  • 14310
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