About: WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	TP53 mutations confer subgroup specific poor survival for children with medulloblastoma. We hypothesized that WNT activation which is associated with improved survival for such children abrogates TP53 related radioresistance and can be used to sensitize TP53 mutant tumors for radiation. We examined the subgroup-specific role of TP53 mutations in a cohort of 314 patients treated with radiation. TP53 wild-type or mutant human medulloblastoma cell-lines and normal neural stem cells were used to test radioresistance of TP53 mutations and the radiosensitizing effect of WNT activation on tumors and the developing brain. Children with WNT/TP53 mutant medulloblastoma had higher 5-year survival than those with SHH/TP53 mutant tumours (100% and 36.6% ± 8.7%, respectively (p < 0.001)). Introduction of TP53 mutation into medulloblastoma cells induced radioresistance (survival fractions at 2Gy (SF2) of 89% ± 2% vs. 57.4% ± 1.8% (p < 0.01)). TP53 mutations confer subgroup specific poor survival for children with medulloblastoma. We hypothesized that WNT activation which is associated with improved survival for such children abrogates TP53 related radioresistance and can be used to sensitize TP53 mutant tumors for radiation. We examined the subgroup-specific role of TP53 mutations in a cohort of 314 patients treated with radiation. TP53 wild-type or mutant human medulloblastoma cell-lines and normal neural stem cells were used to test radioresistance of TP53 mutations and the radiosensitizing effect of WNT activation on tumors and the developing brain. Children with WNT/TP53 mutant medulloblastoma had higher 5-year survival than those with SHH/TP53 mutant tumours (100% and 36.6% ± 8.7%, respectively (p < 0.001)). Introduction of TP53 mutation into medulloblastoma cells induced radioresistance (survival fractions at 2Gy (SF2) of 89% ± 2% vs. 57.4% ± 1.8% (p < 0.01)). (en)
Title	WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma (en)
skos:prefLabel	WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma (en)
skos:notation	RIV/00216224:14110/14:00078705!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED2.1.00/03.0101), P(EE2.3.20.0183)
http://linked.open...iv/cisloPeriodika	174
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Zitterbart, Karel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	56279
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/14:00078705
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	TP53 mutation; medulloblastoma (en)
http://linked.open.../riv/klicoveSlovo	TP53 mutation medulloblastoma
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[346BB46906C3]
http://linked.open...i/riv/nazevZdroje	Acta Neuropathologica Communications
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	60 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Experimental Biomedicine Regional Centre for Applied Molecular Oncology (RECAMO)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	2
http://linked.open...iv/tvurceVysledku	Zitterbart, Karel … Northcott, Paul A Hauser, Peter Fouladi, Maryam Gupta, Nalin Jung, Shin Klekner, Almos Kool, Marcel Korshunov, Andrey Kumabe, Toshihiro Lach, Boleslaw Massimi, Luca Ra, Young Shin Ramaswamy, Vijay Remke, Marc Alman, Benjamin Baskin, Berivan Bognár, Laszlo Bouffet, Eric Bristow, Robert G Bueren, Andre O von Castelo-Branco, Pedro Cho, Byung-Kyu Cho, Yoon-Jae Clifford, Steven C Conter, Cecile Faure Dirks, Peter Eberhart, Charles G Fraser, Michael French, Pim J Gessi, Marco Grajkowska, Wieslawa A Hawkins, Cynthia E Jabado, Nada Jones, David TW Kim, Seung-Ki Leonard, Jeffrey R Liau, Linda M Malkin, David Martin, Dianna C Meir, Erwin G Van Pfaff, Elke Pfister, Stefan M Pietsch, Torsten Pollack, Ian F Pomeroy, Scott L Poon, Raymond Pugh, Trevor J Ray, Peter N Rubin, Joshua B Rutkowski, Stefan Shih, David JH Tse, Ken Vasiljevic, Alexandre Wang, Kyu-Chang Weiss, William A Zhang, Cindy H Zhukova, Nataliya
issn	2051-5960
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1186/s40478-014-0174-y
http://localhost/t...ganizacniJednotka	14110

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