About: High-Risk Multiple Myeloma: Different Definitions, Different Outcomes?

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Multiple myeloma (MM) is a clonal plasma cell malignancy. Although MM is still not completely curable, it can be maintained at the level of a long-term chronic condition. Irrespective of the treatment strategy, relapse is still a major problem for most patients. Approximately 10% to 15% of all MM patients relapse early and have poor prognosis and outcome. Currently, there are many ways of identifying these high-risk patients using cytogenetics or molecular biology. Despite these various approaches to definition of high risk patients, a clear definition of high-risk MM has not been widely accepted. In this review, we discuss and compare various approaches, and their strengths and weaknesses in early identification of high-risk MM patients. Multiple myeloma (MM) is a clonal plasma cell malignancy. Although MM is still not completely curable, it can be maintained at the level of a long-term chronic condition. Irrespective of the treatment strategy, relapse is still a major problem for most patients. Approximately 10% to 15% of all MM patients relapse early and have poor prognosis and outcome. Currently, there are many ways of identifying these high-risk patients using cytogenetics or molecular biology. Despite these various approaches to definition of high risk patients, a clear definition of high-risk MM has not been widely accepted. In this review, we discuss and compare various approaches, and their strengths and weaknesses in early identification of high-risk MM patients. (en)
Title	High-Risk Multiple Myeloma: Different Definitions, Different Outcomes? High-Risk Multiple Myeloma: Different Definitions, Different Outcomes? (en)
skos:prefLabel	High-Risk Multiple Myeloma: Different Definitions, Different Outcomes? High-Risk Multiple Myeloma: Different Definitions, Different Outcomes? (en)
skos:notation	RIV/00216224:14110/14:00075359!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NT13190), Z(MSM0021622434)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Paszeková, Helena Kryukov, Fedor Ševčíková, Sabina Hájek, Roman Kubiczková, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	19165
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/14:00075359
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cytogenetics; GEP; High-risk disease; MGUS; Multiple myeloma; Prognosis (en)
http://linked.open.../riv/klicoveSlovo	High-risk disease GEP Cytogenetics MGUS Multiple myeloma Prognosis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[3E1FF8324892]
http://linked.open...i/riv/nazevZdroje	Clinical lymphoma, myeloma & leukemia
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular signature of centrosome abnormalities and their clinical impact for patients with multiple myeloma
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	14
http://linked.open...iv/tvurceVysledku	Hájek, Roman Kryukov, Fedor Ševčíková, Sabina Kubiczková, Lenka Paszeková, Helena
http://linked.open...ain/vavai/riv/wos	000330912600010
http://linked.open...n/vavai/riv/zamer	From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies
issn	2152-2650
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.clml.2013.09.004
http://localhost/t...ganizacniJednotka	14110

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