About: Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability

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About: Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The exact role of the central acidic domain of Mdm2 in p53 degradation remains unclear. We therefore performed a systematic and comprehensive analysis of the acidic domain using a series of short deletions and found that only a minor part of the domain was indispensable for Mdm2-mediated p53 ubiquitylation. Moreover, we identified a short stretch of acidic amino acids required for p53 degradation but not ubiquitylation, indicating that, in addition to p53 ubiquitylation, the acidic domain might be involved in a critical post-ubiquitylation step in p53 degradation. Rather than representing a single functional domain, different parts of the acidic region perform separate functions in p53 degradation, suggesting that it might be possible to therapeutically target them independently. The exact role of the central acidic domain of Mdm2 in p53 degradation remains unclear. We therefore performed a systematic and comprehensive analysis of the acidic domain using a series of short deletions and found that only a minor part of the domain was indispensable for Mdm2-mediated p53 ubiquitylation. Moreover, we identified a short stretch of acidic amino acids required for p53 degradation but not ubiquitylation, indicating that, in addition to p53 ubiquitylation, the acidic domain might be involved in a critical post-ubiquitylation step in p53 degradation. Rather than representing a single functional domain, different parts of the acidic region perform separate functions in p53 degradation, suggesting that it might be possible to therapeutically target them independently. (en)
Title	Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability (en)
skos:prefLabel	Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability (en)
skos:notation	RIV/00216224:14110/12:00065570!RIV14-MZ0-14110___
http://linked.open...avai/predkladatel	Lékařská fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED1.100/02/0123), P(GA301/09/1324), P(NS10236)
http://linked.open...iv/cisloPeriodika	16
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Uldrijan, Stjepan Kosztyu, Pavlína Cetkovská, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	152546
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/12:00065570
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	p53 degradation; Mdm2; Acidic domain; Mutagenesis; Ubiquitin ligase activity; Binding partner (en)
http://linked.open.../riv/klicoveSlovo	Mdm2 Acidic domain Binding partner Mutagenesis Ubiquitin ligase activity p53 degradation
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[4A481F7D9AA4]
http://linked.open...i/riv/nazevZdroje	FEBS Letters
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Function of the central domain of oncoprotein Mdm2 and its novel binding partners in the regulation of p53 tumour suppressor protein St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC) Therapeutic potential of the inhibition of selected signaling pathways in malignant melanoma cells
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	586
http://linked.open...iv/tvurceVysledku	Uldrijan, Stjepan Cetkovská, Kateřina Kosztyu, Pavlína Vousden, Karen H.
http://linked.open...ain/vavai/riv/wos	000306694800004
issn	0014-5793
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.febslet.2012.05.034
http://localhost/t...ganizacniJednotka	14110

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