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  • The aim of this study was to investigate possible associations of -2548 G/A polymorphism in leptin gene promoter and pregnancy-associated diseases with abnormal fetal growth such as preeclampsia and gestational diabetes. The study was also focused on whether it is rather maternal or fetal variants that determines the pathological growth status. Peripheral or cord blood samples obtained from 49 preeclamptic women and their 39 newborns, 53 healthy controls and their 53 healthy newborns and 48 patients with gestational diabetes mellitus were evaluated for leptin gene (LEP) locus -2548 genotypes. The significantly higher risk for gestational diabetes mellitus was observed in the presence of an allele (AA and AG genotypes) against carriers of GG genotype (OR=2.84, 95%CI 1.14-7.07, p=0.02). There is a significant risk of diabetes mellitus associated to A allele (OR=1.79, 95%CI 1.02-3.14, p=0.03).
  • The aim of this study was to investigate possible associations of -2548 G/A polymorphism in leptin gene promoter and pregnancy-associated diseases with abnormal fetal growth such as preeclampsia and gestational diabetes. The study was also focused on whether it is rather maternal or fetal variants that determines the pathological growth status. Peripheral or cord blood samples obtained from 49 preeclamptic women and their 39 newborns, 53 healthy controls and their 53 healthy newborns and 48 patients with gestational diabetes mellitus were evaluated for leptin gene (LEP) locus -2548 genotypes. The significantly higher risk for gestational diabetes mellitus was observed in the presence of an allele (AA and AG genotypes) against carriers of GG genotype (OR=2.84, 95%CI 1.14-7.07, p=0.02). There is a significant risk of diabetes mellitus associated to A allele (OR=1.79, 95%CI 1.02-3.14, p=0.03). (en)
Title
  • ASSOCIATION OF LEPTIN GENETIC POLYMORPHISM -2548 G/A WITH GESTATIONAL DIABETES
  • ASSOCIATION OF LEPTIN GENETIC POLYMORPHISM -2548 G/A WITH GESTATIONAL DIABETES (en)
skos:prefLabel
  • ASSOCIATION OF LEPTIN GENETIC POLYMORPHISM -2548 G/A WITH GESTATIONAL DIABETES
  • ASSOCIATION OF LEPTIN GENETIC POLYMORPHISM -2548 G/A WITH GESTATIONAL DIABETES (en)
skos:notation
  • RIV/00216224:14110/06:00017421!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 141100002)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 466193
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/06:00017421
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Gestational Diabetes Mellitus; Leptin; Polymorphism; Preeclampsia (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [C7D6EA2D937E]
http://linked.open...i/riv/nazevZdroje
  • Genes and Nutrition
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 2/2006
http://linked.open...iv/tvurceVysledku
  • Bienertová Vašků, Julie
  • Bienert, Petr
  • Dostálová, Zuzana
  • Vašků, Anna
http://linked.open...ain/vavai/riv/wos
  • 000258559500006
http://linked.open...n/vavai/riv/zamer
issn
  • 1555-8932
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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