About: The role of actin in the apoptotic cell death of P19 embryonal carcinoma cells.

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About: The role of actin in the apoptotic cell death of P19 embryonal carcinoma cells. Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The P19 mouse embryonal carcinoma cell line was used as a model for a study of apoptosis accompanying differentiation induced by all-trans retinoic acid (ATRA). Apoptosis was detected both on the basis of morphological features (nuclear fragmentation, blebbing of plasma membrane, and formation of apoptotic bodies), and by using DNA electrophoresis and flow-cytometric measurement of DNA content. Actin cytoskeleton was studied both on morphological and submicroscopic levels. ATRA-treated cells manifested apoptosis-specific changes in the distribution of actin foremost in association with their entry into executive phase of apoptosis, when F-actin cables participated in cell disintegration into apoptotic bodies. Using immunogold labeling, actin was also identified in centers of fragmenting apoptotic nuclei, in the disintegration of which it is likely involved as well. At the same time, a cleavage of actin by active caspase-3 was proved, resulting in the emergence of 32kDa fragment termed fractin. The P19 mouse embryonal carcinoma cell line was used as a model for a study of apoptosis accompanying differentiation induced by all-trans retinoic acid (ATRA). Apoptosis was detected both on the basis of morphological features (nuclear fragmentation, blebbing of plasma membrane, and formation of apoptotic bodies), and by using DNA electrophoresis and flow-cytometric measurement of DNA content. Actin cytoskeleton was studied both on morphological and submicroscopic levels. ATRA-treated cells manifested apoptosis-specific changes in the distribution of actin foremost in association with their entry into executive phase of apoptosis, when F-actin cables participated in cell disintegration into apoptotic bodies. Using immunogold labeling, actin was also identified in centers of fragmenting apoptotic nuclei, in the disintegration of which it is likely involved as well. At the same time, a cleavage of actin by active caspase-3 was proved, resulting in the emergence of 32kDa fragment termed fractin. (en)
Title	The role of actin in the apoptotic cell death of P19 embryonal carcinoma cells. The role of actin in the apoptotic cell death of P19 embryonal carcinoma cells. (en)
skos:prefLabel	The role of actin in the apoptotic cell death of P19 embryonal carcinoma cells. The role of actin in the apoptotic cell death of P19 embryonal carcinoma cells. (en)
skos:notation	RIV/00216224:14110/05:00012573!RIV10-GA0-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA304/00/0403)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Veselská, Renata Neradil, Jakub Svoboda, Augustin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	541388
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/05:00012573
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	apoptosis; actin cytoskeleton; fractin; caspase-3; all-trans retinoic acid; cell differentiation (en)
http://linked.open.../riv/klicoveSlovo	cell differentiation fractin apoptosis caspase-3 actin cytoskeleton all-trans retinoic acid
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[7B79E974B84D]
http://linked.open...i/riv/nazevZdroje	International Journal of Oncology
http://linked.open...in/vavai/riv/obor	EA
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Changes of the cytoskeleton in tumour cell lines during induced apoptosis in relation to different stages of differentiation
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	27
http://linked.open...iv/tvurceVysledku	Neradil, Jakub Veselská, Renata Svoboda, Augustin
issn	1019-6439
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	The role of actin in the apoptotic cell death of P19 embryonal carcinoma cells.

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