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| rdf:type
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| Description
| - Quaternary benzo[c]phenanthridine alkaloids (QBA) are relatively small group of isoquinoline alkaloids interesting for their chemistry and biological activities. They are distributed in a number of plant species of Papaveraceae, Fumariaceae and Rutaceae families. Sanguinarine and chelerythrine are the two best known QBA and their biological activities have been widely studied (Walterová et al., 95). In addition to them about 10 other QBA differing only by substitution on the aromatic rings have been isolated as minor components in several species. The biological effects of these minor QBA have not been described yet. In this preliminary study the biological efect of sanguinarine (SA), chelerythrine (CHE) and their derivatives sanguirubine (SR), chelirubine (CHR) and macarpine (MA) were tested. The alkaloids were isolated from the species Macleaya microcarpa by the common procedure (Dostál et al., 1995). One normal (fibroblasts) and 3 tumor cell lines (HeLa; A431; HL-60) were used as a model object. Cy
- Quaternary benzo[c]phenanthridine alkaloids (QBA) are relatively small group of isoquinoline alkaloids interesting for their chemistry and biological activities. They are distributed in a number of plant species of Papaveraceae, Fumariaceae and Rutaceae families. Sanguinarine and chelerythrine are the two best known QBA and their biological activities have been widely studied (Walterová et al., 95). In addition to them about 10 other QBA differing only by substitution on the aromatic rings have been isolated as minor components in several species. The biological effects of these minor QBA have not been described yet. In this preliminary study the biological efect of sanguinarine (SA), chelerythrine (CHE) and their derivatives sanguirubine (SR), chelirubine (CHR) and macarpine (MA) were tested. The alkaloids were isolated from the species Macleaya microcarpa by the common procedure (Dostál et al., 1995). One normal (fibroblasts) and 3 tumor cell lines (HeLa; A431; HL-60) were used as a model object. Cy (en)
- Kvarterní benzo(c)phenanthridinové alkaloidy (QBA) jsou realtivně malou skupinou izochinolinových alkaloidů zajímavých z hlediska jejich chemické struktury i biologických vlastností. Vyskytují se v rostlinách čeledí Papaveraceae, Fumaraceae a Rutaceae. Nejznámějšími a nejvíce prostudovanými jsou alkaloidy sanguinarin a chelerythrin (Walterová et al., 95). Kromě těchto 2 základních bylo izolováno 10 dalších QBA lišících se pouze substituenty na aromatických jádrech. Ty jsou pouze minoritními složkami v extraktech výše zmíněných rostlin a jejich biologické vlastnosti nebyly dosud podrobněji studovány. V této předběžné studii byly testovány sanguinarin (SA), chelerythrin (CHE), sanguirubin (SR), chelirubin (CHR) a macarpin (MA). Alkaloidy byly izolovány z Macleaya microcarpa (Dostál et al., 1995). Jako modelové objekty byly použity 3 nádorové (HeLa; A431; HL-60) a 1 diploidní buněčná linie (kožní fibroblasty), na kterých byla studována cytotoxicita (IC50), apoptóza a vliv na mikrotubuly. IC5 bylo stanove (cs)
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| Title
| - Biological effects of selected benzo(c)phenanthridine alkaloids
- Biological effects of selected benzo(c)phenanthridine alkaloids (en)
- Biologická aktivita vybraných benzo(c)phenanthridinových alkaloidů (cs)
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| skos:prefLabel
| - Biological effects of selected benzo(c)phenanthridine alkaloids
- Biological effects of selected benzo(c)phenanthridine alkaloids (en)
- Biologická aktivita vybraných benzo(c)phenanthridinových alkaloidů (cs)
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| skos:notation
| - RIV/00216224:14110/04:00011941!RIV08-GA0-14110___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/04:00011941
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - benzo(c)phenanthridine alkaloids; cytotoxicity; apoptosis; microtubule (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...v/mistoKonaniAkce
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| http://linked.open...i/riv/mistoVydani
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| http://linked.open...i/riv/nazevZdroje
| - Sborník XII. Cytoskeletálního klubu
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...iv/tvurceVysledku
| - Slaninová, Iva
- Táborská, Eva
- Vlková, Marcela
- Šinkora, Jiří
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| http://linked.open...vavai/riv/typAkce
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| http://linked.open.../riv/zahajeniAkce
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| number of pages
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| http://purl.org/ne...btex#hasPublisher
| - Společnost pro buněčnou biologii při Československé biologické společnosti
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| http://localhost/t...ganizacniJednotka
| |
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