About: Study of Metallothionein Role in Spinocellular Carcinoma Tissues of Head and Neck Tumours using Brdicka Reaction     Goto   Sponge   Distinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:seeAlso
Description
  • Malignant tumours of head and neck localisation represent serious health problem. All over the world, there is about 650 000 of patients who fall ill with head and neck carcinoma per year. Treatment of this malignity is based especially on the well-timed surgery intervention and radiotherapy. Therefore, alternative ways of diagnostics, which would replace commonly used biopsy in combination with computed tomography, are intensely searched. Attention is devoted especially to molecules, whose levels are changed in body due to malignant process and malignant disease progression. The main objective of this study consisted in determination of metallothionein (/MT)/ levels in tumour tissues of patients suffering from head and neck tumours using differential pulse voltammetry Brdicka reaction. Fifty-five samples of tumour tissue (45 % laryngeal, 40 % oropharyngeal, 9 % hypopharyngeal and 6 % oral cavity cancer) were included in this study. After describing of differences in differential pulse voltammograms of individual tumour localisations, content of MT were determined in the above mentioned localisations. The highest MT level was determined in the tissues of oral tumours (170 +/- 70 mu g/g) followed by hypopharynx (160 +/- 70 mu g/g) and larynx (160 +/- 70 mu g/g). The relatively lowest MT level was determined in tumours of oropharynx (130 +/- 50 mu g/g). MT level related to the size of primary tumour focus oscillates with the increasing tumour size. Notwithstanding this fact, the increasing tendency with tumour disease progression is observable. Similar tendency was determined for MT level related to the metastatic activity of tumours, where MT level increased with tumour spreading into local lymph nodes. Our results supported findings on the possible connection of MT and tumour progression.
  • Malignant tumours of head and neck localisation represent serious health problem. All over the world, there is about 650 000 of patients who fall ill with head and neck carcinoma per year. Treatment of this malignity is based especially on the well-timed surgery intervention and radiotherapy. Therefore, alternative ways of diagnostics, which would replace commonly used biopsy in combination with computed tomography, are intensely searched. Attention is devoted especially to molecules, whose levels are changed in body due to malignant process and malignant disease progression. The main objective of this study consisted in determination of metallothionein (/MT)/ levels in tumour tissues of patients suffering from head and neck tumours using differential pulse voltammetry Brdicka reaction. Fifty-five samples of tumour tissue (45 % laryngeal, 40 % oropharyngeal, 9 % hypopharyngeal and 6 % oral cavity cancer) were included in this study. After describing of differences in differential pulse voltammograms of individual tumour localisations, content of MT were determined in the above mentioned localisations. The highest MT level was determined in the tissues of oral tumours (170 +/- 70 mu g/g) followed by hypopharynx (160 +/- 70 mu g/g) and larynx (160 +/- 70 mu g/g). The relatively lowest MT level was determined in tumours of oropharynx (130 +/- 50 mu g/g). MT level related to the size of primary tumour focus oscillates with the increasing tumour size. Notwithstanding this fact, the increasing tendency with tumour disease progression is observable. Similar tendency was determined for MT level related to the metastatic activity of tumours, where MT level increased with tumour spreading into local lymph nodes. Our results supported findings on the possible connection of MT and tumour progression. (en)
Title
  • Study of Metallothionein Role in Spinocellular Carcinoma Tissues of Head and Neck Tumours using Brdicka Reaction
  • Study of Metallothionein Role in Spinocellular Carcinoma Tissues of Head and Neck Tumours using Brdicka Reaction (en)
skos:prefLabel
  • Study of Metallothionein Role in Spinocellular Carcinoma Tissues of Head and Neck Tumours using Brdicka Reaction
  • Study of Metallothionein Role in Spinocellular Carcinoma Tissues of Head and Neck Tumours using Brdicka Reaction (en)
skos:notation
  • RIV/00216208:11310/12:10126272!RIV13-GA0-11310___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(ED1.1.00/02.0068), P(GAP301/10/0356)
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 172183
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11310/12:10126272
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • metastases; marker; oral cancer; catalytic signal; voltammetry; cancer; electrochemical detection (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • RS - Srbská republika
http://linked.open...ontrolniKodProRIV
  • [217A4C2D2CB4]
http://linked.open...i/riv/nazevZdroje
  • International Journal of Electrochemical Science
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 7
http://linked.open...iv/tvurceVysledku
  • Adam, Vojtěch
  • Babula, Petr
  • Binková, Hana
  • Eckschlager, Tomáš
  • Gumulec, Jaromír
  • Hubálek, Jaromír
  • Hynek, David
  • Kizek, René
  • Křížková, Soňa
  • Krejčová, Ludmila
  • Masařík, Michal
  • Sochor, Jiří
  • Stiborová, Marie
  • Trnková, Libuše
  • Fabrik, Ivo
http://linked.open...ain/vavai/riv/wos
  • 000302730300032
issn
  • 1452-3981
number of pages
http://localhost/t...ganizacniJednotka
  • 11310
is http://linked.open...avai/riv/vysledek of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 85 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software