About: The long pentraxin PTX3: a candidate anti-inflammatory mediator in cardiac surgery

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About: The long pentraxin PTX3: a candidate anti-inflammatory mediator in cardiac surgery Goto Sponge Distinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://prf.sagepub.com/content/28/5/377
Description	Coronary artery bypass grafting (CABG) is performed with the use of cardiopulmonary bypass (CPB) and cardioplegic arrest (CA) of the heart. The advantage of this technique, alternatively referred to as %22on-pump%22 surgery, resides, for the surgeon, in relatively easy access to and manipulation with the non-beating, bloodless heart. However, the advantage that is, thereby, gained by the patient is paid off by an increased susceptibility to postoperative systemic inflammatory response syndrome (SIRS). Under unfavorable conditions, the inflammatory syndrome may develop into life-threatening forms of MODS (multiple organ dysfunction syndrome) or even MOFS (multiple organ failure syndrome). Deliberate avoidance of CPB, also known as %22off-pump%22 surgery, attenuates early postoperative inflammation throughout its trajectory of SIRSRIGHTWARDS ARROWMODSRIGHTWARDS ARROWMOFS, but, in the long run, there appears to be no substantial difference in the overall mortality rates. In the last years, our knowledge of the pathophysiology of surgical inflammation has increased considerably. Recent findings, highlighting the as yet rather obscure role of pentraxin 3 (PTX3) in these processes, are discussed in this review article. Coronary artery bypass grafting (CABG) is performed with the use of cardiopulmonary bypass (CPB) and cardioplegic arrest (CA) of the heart. The advantage of this technique, alternatively referred to as %22on-pump%22 surgery, resides, for the surgeon, in relatively easy access to and manipulation with the non-beating, bloodless heart. However, the advantage that is, thereby, gained by the patient is paid off by an increased susceptibility to postoperative systemic inflammatory response syndrome (SIRS). Under unfavorable conditions, the inflammatory syndrome may develop into life-threatening forms of MODS (multiple organ dysfunction syndrome) or even MOFS (multiple organ failure syndrome). Deliberate avoidance of CPB, also known as %22off-pump%22 surgery, attenuates early postoperative inflammation throughout its trajectory of SIRSRIGHTWARDS ARROWMODSRIGHTWARDS ARROWMOFS, but, in the long run, there appears to be no substantial difference in the overall mortality rates. In the last years, our knowledge of the pathophysiology of surgical inflammation has increased considerably. Recent findings, highlighting the as yet rather obscure role of pentraxin 3 (PTX3) in these processes, are discussed in this review article. (en)
Title	The long pentraxin PTX3: a candidate anti-inflammatory mediator in cardiac surgery The long pentraxin PTX3: a candidate anti-inflammatory mediator in cardiac surgery (en)
skos:prefLabel	The long pentraxin PTX3: a candidate anti-inflammatory mediator in cardiac surgery The long pentraxin PTX3: a candidate anti-inflammatory mediator in cardiac surgery (en)
skos:notation	RIV/00216208:11150/13:10139197!RIV14-MSM-11150___
http://linked.open...avai/predkladatel	Lékařská fakulta v Hradci Králové
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Koláčková, Martina Krejsek, Jan Manďák, Jiří Holubcová, Zdeňka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	85351
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/13:10139197
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	interleukin-10; pentraxin 3; alarmins; sterile inflammation; cardiopulmonary bypass; coronary artery bypass grafting (en)
http://linked.open.../riv/klicoveSlovo	alarmins pentraxin 3 sterile inflammation coronary artery bypass grafting cardiopulmonary bypass interleukin-10
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[C7BD407125B9]
http://linked.open...i/riv/nazevZdroje	Perfusion
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	28
http://linked.open...iv/tvurceVysledku	Krejsek, Jan Koláčková, Martina Manďák, Jiří Kuneš, Pavel Holubcová, Zdeňka
http://linked.open...ain/vavai/riv/wos	000323311800002
issn	0267-6591
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1177/0267659113483799
http://localhost/t...ganizacniJednotka	11150

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