About: Chronic anthracycline cardiotoxicity: molecular and functional analysis with focus on nuclear factor erythroid 2-related factor 2 and mitochondrial biogenesis pathways

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://jpet.aspetjournals.org/content/343/2/468.full
Description	This article deals with the study of mechanisms responsible for development of chronic anthracycline cardiotoxicity with respect to potential role of the Nrf2 (master regulator of antioxidant defense) and PGC1alfa (master regulator of mitochondrial biogenesis pathway). Our data suggest that there is no coordinated response of Nrf2 pathway in anthracycline cardiotoxicity, while mitochondrial biogenesis seemed rather suppressed, especially in the follow up period. This article deals with the study of mechanisms responsible for development of chronic anthracycline cardiotoxicity with respect to potential role of the Nrf2 (master regulator of antioxidant defense) and PGC1alfa (master regulator of mitochondrial biogenesis pathway). Our data suggest that there is no coordinated response of Nrf2 pathway in anthracycline cardiotoxicity, while mitochondrial biogenesis seemed rather suppressed, especially in the follow up period. (en)
Title	Chronic anthracycline cardiotoxicity: molecular and functional analysis with focus on nuclear factor erythroid 2-related factor 2 and mitochondrial biogenesis pathways Chronic anthracycline cardiotoxicity: molecular and functional analysis with focus on nuclear factor erythroid 2-related factor 2 and mitochondrial biogenesis pathways (en)
skos:prefLabel	Chronic anthracycline cardiotoxicity: molecular and functional analysis with focus on nuclear factor erythroid 2-related factor 2 and mitochondrial biogenesis pathways Chronic anthracycline cardiotoxicity: molecular and functional analysis with focus on nuclear factor erythroid 2-related factor 2 and mitochondrial biogenesis pathways (en)
skos:notation	RIV/00216208:11150/12:10124113!RIV13-MSM-11150___
http://linked.open...avai/predkladatel	Lékařská fakulta v Hradci Králové
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(GA305/09/0416), S
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Hroch, Miloš Staňková, Pavla Geršl, Vladimír Štěrba, Martin Jirkovský, Eduard Červinková, Zuzana Brčáková, Eva Popelová, Olga Mičuda, Stanislav Adamcová, Michaela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	127136
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/12:10124113
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mitochondrial biogenesis; antioxidant defense; Nrf2; oxidative stress; anthracyclines (en)
http://linked.open.../riv/klicoveSlovo	anthracyclines oxidative stress Nrf2 antioxidant defense mitochondrial biogenesis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[9D1F39FB11B4]
http://linked.open...i/riv/nazevZdroje	Journal of Pharmacology and Experimental Therapeutics
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	10 (xsd:int)
http://linked.open...cetTvurcuVysledku	13 (xsd:int)
http://linked.open...vavai/riv/projekt	Myocardial damage induced by anticancer drugs and ischemia-reperfusion: new possibilities of pharmacological cardioprotection.
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	343
http://linked.open...iv/tvurceVysledku	Adamcová, Michaela Hašková, Pavlína Mičuda, Stanislav Vávrová, Anna Šimůnek, Tomáš Geršl, Vladimír Jirkovský, Eduard Popelová, Olga Staňková, Pavla Červinková, Zuzana Štěrba, Martin Hroch, Miloš Doleželová, Eva
http://linked.open...ain/vavai/riv/wos	000309979400024
issn	0022-3565
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1124/jpet.112.198358
http://localhost/t...ganizacniJednotka	11150
is http://linked.open...avai/riv/vysledek of	Chronic anthracycline cardiotoxicity: molecular and functional analysis with focus on nuclear factor erythroid 2-related factor 2 and mitochondrial biogenesis pathways

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