About: Occurrence and significance of the nuclear transcription factor Krüppel-like factor 4 (KLF4) in the vessel wall

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Practically all mammalian cells including human can switch, according to micro- or macroenvironmental conditions, from states of cellular quiescence to inflammatory activation and vice versa. Along with recent knowledge, cellular quiescence is not a passive, but a highly active state with broad engagement of the cell synthetic and secretory machinery. Inflammatory activation is a beneficial process in cases of infection; however, if its control fails, it may degrade into autoimmune diseases or cancer growth. Control over cellular quiescence is exerted predominantly by a set of zincfinger transcription proteins, referred to as Krüppel-like factors (KLFs). This review article offers recent information concerning activities of Krüppel-like factor 4 in the vascular wall. Practically all mammalian cells including human can switch, according to micro- or macroenvironmental conditions, from states of cellular quiescence to inflammatory activation and vice versa. Along with recent knowledge, cellular quiescence is not a passive, but a highly active state with broad engagement of the cell synthetic and secretory machinery. Inflammatory activation is a beneficial process in cases of infection; however, if its control fails, it may degrade into autoimmune diseases or cancer growth. Control over cellular quiescence is exerted predominantly by a set of zincfinger transcription proteins, referred to as Krüppel-like factors (KLFs). This review article offers recent information concerning activities of Krüppel-like factor 4 in the vascular wall. (en)
Title	Occurrence and significance of the nuclear transcription factor Krüppel-like factor 4 (KLF4) in the vessel wall Occurrence and significance of the nuclear transcription factor Krüppel-like factor 4 (KLF4) in the vessel wall (en)
skos:prefLabel	Occurrence and significance of the nuclear transcription factor Krüppel-like factor 4 (KLF4) in the vessel wall Occurrence and significance of the nuclear transcription factor Krüppel-like factor 4 (KLF4) in the vessel wall (en)
skos:notation	RIV/00216208:11150/09:00208794!RIV10-MSM-11150___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620812)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Krejsek, Jan Kuneš, Pavel Holubcová, Zdeňka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	330803
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/09:00208794
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	endothelial phenotype; inflammatory cytokines; shear stress; transcription factors; arterial injury; smooth muscle cells (en)
http://linked.open.../riv/klicoveSlovo	arterial injury endothelial phenotype transcription factors smooth muscle cells shear stress inflammatory cytokines
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[828F96D17CA1]
http://linked.open...i/riv/nazevZdroje	Acta Medica (Hradec Králové)
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	52
http://linked.open...iv/tvurceVysledku	Krejsek, Jan Kuneš, Pavel Holubcová, Zdeňka
http://linked.open...n/vavai/riv/zamer	Chronická onemocnění vznikající na podkladě nepřiměřené reaktivity imunitního systému, jejich patogeneze a možnosti včasné diagnostiky a léčby
issn	1211-4286
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	11150
is http://linked.open...avai/riv/vysledek of	Occurrence and significance of the nuclear transcription factor Krüppel-like factor 4 (KLF4) in the vessel wall Occurrence and significance of the nuclear transcription factor Krüppel-like factor 4 (KLF4) in the vessel wall Occurrence and significance of the nuclear transcription factor Krüppel-like factor 4 (KLF4) in the vessel wall Occurrence and significance of the nuclear transcription factor Krüppel-like factor 4 (KLF4) in the vessel wall

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