About: Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma - beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma     Goto   Sponge   Distinct   Permalink

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  • We studied 9 lung tumors previously diagnosed as biphasic pulmonary blastoma (PB). This study suggests that beta-catenin gene mutations may play a role in the tumorigenesis of CPB. Although CPB and BCS have often been grouped together as biphasic PB, they are different entities based on immunohistochemical and molecular analysis of beta-catenin. Immunostaining for beta-catenin is useful for the discrimination.
  • We studied 9 lung tumors previously diagnosed as biphasic pulmonary blastoma (PB). This study suggests that beta-catenin gene mutations may play a role in the tumorigenesis of CPB. Although CPB and BCS have often been grouped together as biphasic PB, they are different entities based on immunohistochemical and molecular analysis of beta-catenin. Immunostaining for beta-catenin is useful for the discrimination. (en)
  • Mutace v genu pro beta katenin vedou k jeho akumulaci a aberantní lokalizaci v buňkách (jádro/cytoplazma). Nedávno jsme prokázali specifickou lokalizaci mutovaného beta-kateninu u málo diferencovaného adenokarcinomu typu fetálních plic (L-FLAC) a epiteliálního prototypu klasického pulmonálního blastomu (CPB) - dobře diferencovaného adenokarcinomu (WDFA). Beta-katenin jsme nyní studovali u 9 nádorů plic, které byly histologicky definovány jako CPB a blastomatoidní varianty karcinosarkomu (BCS). Všechny CPB vykazovaly aberantní lokalizaci kateninu, kdežto BCS vykazovaly minimální aberantní lokalizaci tohoto proteinu. Mutační analýza exonu 3 genu pro beta katenin prokázala, že 3 CPB se vyznačovaly missense mutacemi (S29F, S37F, S37F), které chyběly u BCS. Tyto výsledky ukazují odlišnosti mezi CPB a BCS a poukazují na vhodnost imunodetekce beta kateninu pro odlišení těchto nádorů. (cs)
Title
  • Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma - beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma
  • Aberantní jaderná/cytoplasmatická lokalizace a genové mutace beta-cateninu u klasického pulmonálního blastomu - imunohistochem. detekce beta-cateninu je užitečná pro rozlišení mezi klasickým pulmonálním blastomem a blastomatoidní variantou karcinosarcomu (cs)
  • Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma - beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma (en)
skos:prefLabel
  • Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma - beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma
  • Aberantní jaderná/cytoplasmatická lokalizace a genové mutace beta-cateninu u klasického pulmonálního blastomu - imunohistochem. detekce beta-cateninu je užitečná pro rozlišení mezi klasickým pulmonálním blastomem a blastomatoidní variantou karcinosarcomu (cs)
  • Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma - beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma (en)
skos:notation
  • RIV/00216208:11150/07:00004246!RIV08-MSM-11150___
http://linked.open.../vavai/riv/strany
  • 921;927
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 7
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 408297
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  • RIV/00216208:11150/07:00004246
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http://linked.open.../riv/klicovaSlova
  • Aberrant; nuclear/cytoplasmic; localization; mutation; beta-catenin; classic; pulmonary; blastoma; beta-catenin; immunostaining; useful; distinguishing; between; classic; pulmonary; blastoma; blastomatoid; variant; carcinosarcoma (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [9BA7B4CB436A]
http://linked.open...i/riv/nazevZdroje
  • American Journal of Surgical Pathology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 28
http://linked.open...iv/tvurceVysledku
  • Rešl, Milan
issn
  • 0147-5185
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  • 11150
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