About: Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: A study of salicylaldehyde isonicotinoyl hydrazone (SIH)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	V této studii bylo zjištěno, že chelátor železa SIH nemá potenciál oslabovat protinádorovou účinnost antracyklinů a zároveň je schopen navodit signifikantní kardioprotekci proti chronické antracyklinové kardiotoxicitě u králíka. Nicméně, bylo dále zjištěno, že tato látka sdílí paradoxní dávkovou závislost s ostatními aroylhydrazony. (cs) In this study, it was revealed that iron chelator SIH has no potential to blunt anticancer efficacy of anthracyclines and it is able to afford significant cardioprotection against chronic anthracycline cardiotoxicity in rabbits. However, it was revealed that it shares the same paradox dose-dependency with other aroylhydrazones. In this study, it was revealed that iron chelator SIH has no potential to blunt anticancer efficacy of anthracyclines and it is able to afford significant cardioprotection against chronic anthracycline cardiotoxicity in rabbits. However, it was revealed that it shares the same paradox dose-dependency with other aroylhydrazones. (en)
Title	Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: A study of salicylaldehyde isonicotinoyl hydrazone (SIH) Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: A study of salicylaldehyde isonicotinoyl hydrazone (SIH) (en) Kardioprotekce proti chronické antracyklinové kardiotoxicitě pomocí chelatace železa: studium salicyladehyd isonikotinoyl hydrazonu (cs)
skos:prefLabel	Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: A study of salicylaldehyde isonicotinoyl hydrazone (SIH) Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: A study of salicylaldehyde isonicotinoyl hydrazone (SIH) (en) Kardioprotekce proti chronické antracyklinové kardiotoxicitě pomocí chelatace železa: studium salicyladehyd isonikotinoyl hydrazonu (cs)
skos:notation	RIV/00216208:11150/07:00003855!RIV08-MSM-11150___
http://linked.open.../vavai/riv/strany	150;166
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(GP305/05/P156), V, Z(MSM0021620820), Z(MZ0FNHK2005)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Gunčová, Ivana Mazurová, Yvona Palička, Vladimír Geršl, Vladimír Štěrba, Martin Popelová, Olga Potáčová, Anna Adamcová, Michaela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	427568
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/07:00003855
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cardioprotection; iron chelator; cardiotoxicity; anthracyclines; salicylaldehyde isonicotinoyl hydrazone; SIH (en)
http://linked.open.../riv/klicoveSlovo	salicylaldehyde isonicotinoyl hydrazone cardioprotection anthracyclines cardiotoxicity SIH iron chelator
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[DB5EB1421419]
http://linked.open...i/riv/nazevZdroje	Toxicology
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of protective effects of novel iron chelators in the heart injury induced by oxidative stress and anthracycline cytostatics
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	235
http://linked.open...iv/tvurceVysledku	Adamcová, Michaela Palička, Vladimír Geršl, Vladimír Popelová, Olga Štěrba, Martin Mazurová, Yvona Potáčová, Anna Gunčová, Ivana
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement Nové diagnostické indikátory a léčebné postupy v závislosti na různých obdobích života s důrazem na stáří
issn	0300-483X
number of pages	17 (xsd:int)
http://localhost/t...ganizacniJednotka	11150
is http://linked.open...avai/riv/vysledek of	Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: A study of salicylaldehyde isonicotinoyl hydrazone (SIH) Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: A study of salicylaldehyde isonicotinoyl hydrazone (SIH) Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: A study of salicylaldehyde isonicotinoyl hydrazone (SIH)

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