About: Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity

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About: Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this study the cardioprotective effects of the novel lipophilic iron chelator against chronic anthracycline cardiotoxicity were investigated. Using 10 mg/kg of the chelator administered 30 min before the every daunorubicin dose the significant cardioprotection was obtained (as shown by prevention of cardiac-related deaths, improved functional, biochemical and morphological parameters). On the other hand escalation of the dose to the 25 mg/kg did not improved cardiovascular parameters, on the contrary, the cardioprotective potential was lost and early extracardiac toxicity was observed. In this study the cardioprotective effects of the novel lipophilic iron chelator against chronic anthracycline cardiotoxicity were investigated. Using 10 mg/kg of the chelator administered 30 min before the every daunorubicin dose the significant cardioprotection was obtained (as shown by prevention of cardiac-related deaths, improved functional, biochemical and morphological parameters). On the other hand escalation of the dose to the 25 mg/kg did not improved cardiovascular parameters, on the contrary, the cardioprotective potential was lost and early extracardiac toxicity was observed. (en) V této studii byly sledovány kardioprotektivní účinky nového chelátoru železa vůči antracycklinové kardiotoxicitě. Chelátor podaný v dávce 10 mg/kg 30 min před daunorubicinem navodil signifikantní kardioprotekci (jak je patrno z prevence kardiální mortality, zlepšení funkčních biochemických a morfologických parametrů). Na druhou stranu, zvýšení dávky na 25 mg/kg nevedlo ke zlepšení kardiovaskulárních parametrů, naopak, kardioprotektivní potenciál vymizel a byla pozorována časná extrakardiální toxicita. (cs)
Title	Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity (en) Kardioprotektivní účinky nového chelátoru železa, pyridoxal 2-chlorbenzoyl hydrazonu, na modelu daunorubicinem-indukované kardiotoxicity u králíka (cs)
skos:prefLabel	Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity (en) Kardioprotektivní účinky nového chelátoru železa, pyridoxal 2-chlorbenzoyl hydrazonu, na modelu daunorubicinem-indukované kardiotoxicity u králíka (cs)
skos:notation	RIV/00216208:11150/06:00004259!RIV07-MSM-11150___
http://linked.open.../vavai/riv/strany	1336;1347
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(GP305/05/P156), V, Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Mazurová, Yvona Geršl, Vladimír Štěrba, Martin Popelová, Olga Potáčová, Anna Adamcová, Michaela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	467780
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/06:00004259
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cardiotoxicity; cardioprotection; iron chelator; pyridoxal 2-chlorobenzoyl hydrazone; anthracycline (en)
http://linked.open.../riv/klicoveSlovo	cardioprotection anthracycline cardiotoxicity iron chelator pyridoxal 2-chlorobenzoyl hydrazone
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[EDCB4407D618]
http://linked.open...i/riv/nazevZdroje	Journal of Pharmacology and Experimental Therapeutics
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of protective effects of novel iron chelators in the heart injury induced by oxidative stress and anthracycline cytostatics
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	319
http://linked.open...iv/tvurceVysledku	Adamcová, Michaela Geršl, Vladimír Popelová, Olga Štěrba, Martin Mazurová, Yvona Potáčová, Anna
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement
issn	0022-3565
number of pages	12 (xsd:int)
http://localhost/t...ganizacniJednotka	11150
is http://linked.open...avai/riv/vysledek of	Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity

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