About: Expression of cytoskeletal proteins in hepatic stellate cells isolated from normal and cirrhotic rat liver

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Hepatic stellate cells (HSC) are located in Disse spaces of normal rat liver. In fibrotic liver they become activated, proliferate and they undergo transdifferentiation into myofibroblast-like cells. Changes in the cell phenotype are accompanied by changes in the cellular cytoskeleton. We have studied the expression of alpha-smooth muscle actin and intermediate filament proteins vimentin, desmin and glial fibrillary acidic protein (GFAP) by immunocytochemistry in HSC cultured for 2 or 7 days after isolation. HSC were isolated from normal or CCl4-cirrhotic rat liver. Hepatic stellate cells (HSC) are located in Disse spaces of normal rat liver. In fibrotic liver they become activated, proliferate and they undergo transdifferentiation into myofibroblast-like cells. Changes in the cell phenotype are accompanied by changes in the cellular cytoskeleton. We have studied the expression of alpha-smooth muscle actin and intermediate filament proteins vimentin, desmin and glial fibrillary acidic protein (GFAP) by immunocytochemistry in HSC cultured for 2 or 7 days after isolation. HSC were isolated from normal or CCl4-cirrhotic rat liver. (en) Jaterní hvězdicové buňky se nacházejí v Disseho prostorech normálních jater. Ve fibrotických játrech se aktivují, proliferují a přeměňují se na buňky podobné myofibroblastům. Změny fenotypu jsou provázeny změnami buněčného cytoskeletu. Studovali jsme změny hladkosvalového alfa-aktinu, desminu, vimentinu a GFAP v buňkách izolovaných z normálních i cirhotických jater. (cs)
Title	Expression of cytoskeletal proteins in hepatic stellate cells isolated from normal and cirrhotic rat liver Exprese bílkovin cytoskeletu v jaterních hvězdicových buňkách izolovaných z normálních a cirhotických jater (cs) Expression of cytoskeletal proteins in hepatic stellate cells isolated from normal and cirrhotic rat liver (en)
skos:prefLabel	Expression of cytoskeletal proteins in hepatic stellate cells isolated from normal and cirrhotic rat liver Exprese bílkovin cytoskeletu v jaterních hvězdicových buňkách izolovaných z normálních a cirhotických jater (cs) Expression of cytoskeletal proteins in hepatic stellate cells isolated from normal and cirrhotic rat liver (en)
skos:notation	RIV/00216208:11150/05:00003668!RIV06-MSM-11150___
http://linked.open.../vavai/riv/strany	137;144
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/03/1513), Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Kanta, Jiří Köhlerová, Renata
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	521222
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/05:00003668
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Liver cirhosis; Carbon tetrachloride; Hepatic stellate cells; Desmin; Glial fibrillary acidic protein; alpha-smooth muscle actin (en)
http://linked.open.../riv/klicoveSlovo	Hepatic stellate cells Desmin Glial fibrillary acidic protein Liver cirhosis alpha-smooth muscle actin Carbon tetrachloride
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[63CE27E2D379]
http://linked.open...i/riv/nazevZdroje	Acta Medica (Hradec Králové)
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Expression of connective tissue proteins in rat hepatic stellate cells
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	48
http://linked.open...iv/tvurceVysledku	Kanta, Jiří Köhlerová, Renata
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement
issn	1211-4286
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	11150
is http://linked.open...avai/riv/vysledek of	Expression of cytoskeletal proteins in hepatic stellate cells isolated from normal and cirrhotic rat liver

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