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Description
| - Pentamidine treatment may cause sudden cardiac death by provoking cardiac arrhythmias. It is known that pentamidine disrupt trafficking of hERG potassium channel. Here we demonstrate direct interaction of pentamidine with KIR2.X channel resulting in functional block of IK1 current.
- Pentamidine treatment may cause sudden cardiac death by provoking cardiac arrhythmias. It is known that pentamidine disrupt trafficking of hERG potassium channel. Here we demonstrate direct interaction of pentamidine with KIR2.X channel resulting in functional block of IK1 current. (en)
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Title
| - The anti-protozoal drug pentamidine blocks K(IR)2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel
- The anti-protozoal drug pentamidine blocks K(IR)2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel (en)
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skos:prefLabel
| - The anti-protozoal drug pentamidine blocks K(IR)2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel
- The anti-protozoal drug pentamidine blocks K(IR)2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel (en)
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skos:notation
| - RIV/00216208:11140/10:10103267!RIV12-MSM-11140___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11140/10:10103267
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - channel; region; pore; cytoplasmic; entering; current; rectifier; inward; KIR2.x-mediated; blocks; pentamidine; drug; anti-protozoal (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - British Journal of Pharmacology
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Houtman, Marien J.C.
- Nalos, Lukáš
- Rook, Martin B.
- Vos, Marc A.
- de Boer, Teun P.
- van der Heyden, Marcel A.G.
- Antoons, G.
- Beekman, J.D.M.
- Kok, B.
- Opthof, T.
- Stary, A.
- de Groot, B. L.
- van Veen, T.A.B.
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1111/j.1476-5381.2010.00658.x
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http://localhost/t...ganizacniJednotka
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is http://linked.open...avai/riv/vysledek
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