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Description
| - We designed and synthesized 40 analogues of dofetilide and established structure-activity relationships for their interaction with hERG potassium channel. The data were derived with the aim to specify structural features that give rise to hERG toxicity.
- We designed and synthesized 40 analogues of dofetilide and established structure-activity relationships for their interaction with hERG potassium channel. The data were derived with the aim to specify structural features that give rise to hERG toxicity. (en)
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Title
| - Exploring chemical substructures essential for hERG K(+) Channel blockade by synthesis and biological evaluation of dofetilide analogues
- Exploring chemical substructures essential for hERG K(+) Channel blockade by synthesis and biological evaluation of dofetilide analogues (en)
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skos:prefLabel
| - Exploring chemical substructures essential for hERG K(+) Channel blockade by synthesis and biological evaluation of dofetilide analogues
- Exploring chemical substructures essential for hERG K(+) Channel blockade by synthesis and biological evaluation of dofetilide analogues (en)
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skos:notation
| - RIV/00216208:11140/09:10103260!RIV12-MSM-11140___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11140/09:10103260
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - structure-activity relationships; radioligand binding assays; ion channels; hERG; dofetilide; cardiotoxicity (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Nalos, Lukáš
- Rook, Martin B.
- Vos, Marc A.
- van der Heyden, Marcel A.G.
- Brussee, Johannes
- IJzerman, Adriaan, P.
- Klaasse, Elisabeth
- Shagufta, Dong Guo
- de Vries, Henk
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
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http://localhost/t...ganizacniJednotka
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is http://linked.open...avai/riv/vysledek
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