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rdf:type
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Description
| - Cadherins and protocadherins are cell adhesion proteins that play an important role in neuronal migration, differentiation and synaptogenesis, properties that make them targets to consider in schizophrenia (SZ) and bipolar disorder (BD) pathogenesis. Consequently, allelic variation occurring in protocadherin and cadherin encoding genes that map to regions of the genome targeted in SZ and BD linkage studies are particularly strong candidates to consider. One such set of candidate genes is the 5q31-linked PCDH family, which consists of more than 50 exons encoding three related, though distinct family members - alpha, beta, and gamma - which can generate thousands of different protocadherin proteins through alternative promoter usage and cis-alternative splicing. In this study, we focused on a SNP, rs31745, which is located in a putative PCDH alpha enhancer mapped by ChIP-chip using antibodies to covalently modified histone H3.
- Cadherins and protocadherins are cell adhesion proteins that play an important role in neuronal migration, differentiation and synaptogenesis, properties that make them targets to consider in schizophrenia (SZ) and bipolar disorder (BD) pathogenesis. Consequently, allelic variation occurring in protocadherin and cadherin encoding genes that map to regions of the genome targeted in SZ and BD linkage studies are particularly strong candidates to consider. One such set of candidate genes is the 5q31-linked PCDH family, which consists of more than 50 exons encoding three related, though distinct family members - alpha, beta, and gamma - which can generate thousands of different protocadherin proteins through alternative promoter usage and cis-alternative splicing. In this study, we focused on a SNP, rs31745, which is located in a putative PCDH alpha enhancer mapped by ChIP-chip using antibodies to covalently modified histone H3. (en)
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Title
| - Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia
- Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia (en)
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skos:prefLabel
| - Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia
- Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia (en)
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skos:notation
| - RIV/00216208:11120/08:00003125!RIV12-MZ0-11120___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/08:00003125
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - protocadherin; cadherin schizophrenia; bipolar disorder; chromatin (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Novák, Tomáš
- Stopková, Pavla
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1016/j.schres.2008.04.013
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http://localhost/t...ganizacniJednotka
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is http://linked.open...avai/riv/vysledek
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