About: Long-term prophylactic treatment of attacks of vertigo in Menire's disease - comparison of a high with a low dosage of betahistine in an open trial

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Despite the considerable limitations of an open, non-masked trial, particularly in Menire's disease (MD), a higher dosage of betahistine-dihydrochloride and a long-term treatment seems to be more effective than a low dosage and short-term treatment. Objective. To evaluate the prophylactic effects of a low versus high dosage long-term treatment with betahistine-dihydrochloride on the number of attacks in MD. Patients and methods. We performed an open, non-masked trial, in which patients with MD received either a low dosage of betahistine-dihydrochloride (16 or 24 mg tid) or a higher dosage of 48 mg tid for at least 12 months. The outcome measure was the number of attacks per month during a 3-month period. Non-parametric tests and a random effects model were used for statistical analysis. Results. A total of 112 patients were included in the analysis: 50 received betahistine-dihydrochloride in a low dosage (16 mg tid, n=21, 24 mg, n=29) and 62 received 48 mg tid. Follow-up examination every 3 month Despite the considerable limitations of an open, non-masked trial, particularly in Menire's disease (MD), a higher dosage of betahistine-dihydrochloride and a long-term treatment seems to be more effective than a low dosage and short-term treatment. Objective. To evaluate the prophylactic effects of a low versus high dosage long-term treatment with betahistine-dihydrochloride on the number of attacks in MD. Patients and methods. We performed an open, non-masked trial, in which patients with MD received either a low dosage of betahistine-dihydrochloride (16 or 24 mg tid) or a higher dosage of 48 mg tid for at least 12 months. The outcome measure was the number of attacks per month during a 3-month period. Non-parametric tests and a random effects model were used for statistical analysis. Results. A total of 112 patients were included in the analysis: 50 received betahistine-dihydrochloride in a low dosage (16 mg tid, n=21, 24 mg, n=29) and 62 received 48 mg tid. Follow-up examination every 3 month (en)
Title	Long-term prophylactic treatment of attacks of vertigo in Menire's disease - comparison of a high with a low dosage of betahistine in an open trial Long-term prophylactic treatment of attacks of vertigo in Menire's disease - comparison of a high with a low dosage of betahistine in an open trial (en)
skos:prefLabel	Long-term prophylactic treatment of attacks of vertigo in Menire's disease - comparison of a high with a low dosage of betahistine in an open trial Long-term prophylactic treatment of attacks of vertigo in Menire's disease - comparison of a high with a low dosage of betahistine in an open trial (en)
skos:notation	RIV/00216208:11120/08:00002197!RIV11-MSM-11120___
http://linked.open...avai/riv/aktivita	N
http://linked.open...avai/riv/aktivity	N
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Hahn, A.
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	377149
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/08:00002197
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Meniere's disease; betahistine-dihydrochloride; attacks of vertigo; long-term treatment (en)
http://linked.open.../riv/klicoveSlovo	Meniere's disease attacks of vertigo betahistine-dihydrochloride long-term treatment
http://linked.open...odStatuVydavatele	NO - Norské království
http://linked.open...ontrolniKodProRIV	[463A14239FA0]
http://linked.open...i/riv/nazevZdroje	Acta Oto-Laryngologica
http://linked.open...in/vavai/riv/obor	FF
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	128
http://linked.open...iv/tvurceVysledku	Hahn, Aleš
http://linked.open...ain/vavai/riv/wos	000255042200005
issn	0001-6489
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	Long-term prophylactic treatment of attacks of vertigo in Menire's disease - comparison of a high with a low dosage of betahistine in an open trial Long-term prophylactic treatment of attacks of vertigo in Menire's disease - comparison of a high with a low dosage of betahistine in an open trial Long-term prophylactic treatment of attacks of vertigo in Menire's disease - comparison of a high with a low dosage of betahistine in an open trial

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