About: Reinnervation of the rat musculocutaneous nerve stump after its direct reconnection with the C5 spinal cord segment by the nerve graft following avulsion of the ventral spinal roots     Goto   Sponge   Distinct   Permalink

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Description
  • Práce popisuje reinervaci pahýlu krysího nervus musculocutaneus po jeho přímém znovuspojení na míšní segment C5 nervovým štěpem následkem avulze ventrální míšních kořenů: srovnání intratekálního podání mozkově derivovaného neurotrofického faktoru a Cerebrosylinu (cs)
  • Experimental model based on the C5 ventral root avulsion was used to evaluate the efficacy of brain-derived neurotrophic factor (BDNF) and Cerebrolysin treatment on motor neuron maintenance and survival resulted in the functional reinnervation of the nerve stump. In contrast to vehicle, BDNF treatment reduced the loss and atrophy of motor neurons and enhanced the regrowth axon sprouts into the distal stump of musculocutaneous nerve. However, the axon diameter of the myelinated fibers was smaller than those of control rats. The morphometric results were related to a low score in behavioral test similar to vehicle-treated rats. Cerebrolysin treatment greatly protected the motor neurons against cell death. Moreover, morphometric features of myelinated axons were better than those of rats treated with vehicle or BDNF. The mean score of grooming test suggested better results of the functional motor reinnervation than after BDNF administration.
  • Experimental model based on the C5 ventral root avulsion was used to evaluate the efficacy of brain-derived neurotrophic factor (BDNF) and Cerebrolysin treatment on motor neuron maintenance and survival resulted in the functional reinnervation of the nerve stump. In contrast to vehicle, BDNF treatment reduced the loss and atrophy of motor neurons and enhanced the regrowth axon sprouts into the distal stump of musculocutaneous nerve. However, the axon diameter of the myelinated fibers was smaller than those of control rats. The morphometric results were related to a low score in behavioral test similar to vehicle-treated rats. Cerebrolysin treatment greatly protected the motor neurons against cell death. Moreover, morphometric features of myelinated axons were better than those of rats treated with vehicle or BDNF. The mean score of grooming test suggested better results of the functional motor reinnervation than after BDNF administration. (en)
Title
  • Reinervace pahýlu krysího nervus musculocutaneus po jeho přímém znovuspojení na míšní segment C5 nervovým štěpem následkem avulze ventrální míšních kořenů (cs)
  • Reinnervation of the rat musculocutaneous nerve stump after its direct reconnection with the C5 spinal cord segment by the nerve graft following avulsion of the ventral spinal roots
  • Reinnervation of the rat musculocutaneous nerve stump after its direct reconnection with the C5 spinal cord segment by the nerve graft following avulsion of the ventral spinal roots (en)
skos:prefLabel
  • Reinervace pahýlu krysího nervus musculocutaneus po jeho přímém znovuspojení na míšní segment C5 nervovým štěpem následkem avulze ventrální míšních kořenů (cs)
  • Reinnervation of the rat musculocutaneous nerve stump after its direct reconnection with the C5 spinal cord segment by the nerve graft following avulsion of the ventral spinal roots
  • Reinnervation of the rat musculocutaneous nerve stump after its direct reconnection with the C5 spinal cord segment by the nerve graft following avulsion of the ventral spinal roots (en)
skos:notation
  • RIV/00216208:11120/04:00001133!RIV/2005/MZ0/111205/N
http://linked.open.../vavai/riv/strany
  • 425;432
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NF6658)
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 584121
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11120/04:00001133
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Reinnervation;musculocutaneous;nerve;stump;after;direct;reconnection;spinal;segment;nerve;graft;following;avulsion;ventral;spinal;roots;comparison;intrathecal;administration;brain-derived;neurotrophic (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [231E7E8ABC1F]
http://linked.open...i/riv/nazevZdroje
  • Experimental Brain Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 159
http://linked.open...iv/tvurceVysledku
  • Haninec, Pavel
  • Houšťava, Ladislav
  • Šámal, Filip
issn
  • 0014-4819
number of pages
http://localhost/t...ganizacniJednotka
  • 11120
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