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| rdf:type
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| Description
| - Aktinické keratózy jsou prekancerózy, které se mohou transformovat na spianliom. Imiquimod je určen k léčbě aktinických keratóz. Ve skupině 13 pacientů byla sledována genová exprese před, během a po terapii. Byly vyšetřovány geny, které kódují prozánětlivé cytokiny nebo jejich receptory, adhezivní molekuly, antiapoptotické proteiny, p53 a toll-like receptory s použitím RT-PCR. Bylo prokázáno, že lze najít specifické rozdíly v genové expresi mezi aktinickými keratózami a nepostiženou kůží (cs)
- Background Actinic keratoses (AKs) are premalignant lesions that can progress into squamous cell carcinoma. Imiquimod, which belongs to the new class of immune-response modifiers, was recently shown to be effective in the treatment of AKs. The underlying mechanisms are not fully understood. Objectives To study the expression of individual genes in uninvolved skin and AKs before therapy and to elucidate the way in which the expression of these genes is influenced by imiquimod therapy. Methods We treated 13 patients with AK with imiquimod and compared gene expression before, during (five patients) and after (eight patients) therapy with that in uninvolved skin. We analysed genes coding for inflammatory cytokines or their receptors, adhesion molecules, anti-apoptotic proteins, p53 and toll-like receptors (TLRs) by reverse-transcriptase polymerase chain reaction. Results Comparing uninvolved skin and untreated AK, we found significant differences in the expression of interleukin (IL)-6, hurpin, TLR7 and
- Background Actinic keratoses (AKs) are premalignant lesions that can progress into squamous cell carcinoma. Imiquimod, which belongs to the new class of immune-response modifiers, was recently shown to be effective in the treatment of AKs. The underlying mechanisms are not fully understood. Objectives To study the expression of individual genes in uninvolved skin and AKs before therapy and to elucidate the way in which the expression of these genes is influenced by imiquimod therapy. Methods We treated 13 patients with AK with imiquimod and compared gene expression before, during (five patients) and after (eight patients) therapy with that in uninvolved skin. We analysed genes coding for inflammatory cytokines or their receptors, adhesion molecules, anti-apoptotic proteins, p53 and toll-like receptors (TLRs) by reverse-transcriptase polymerase chain reaction. Results Comparing uninvolved skin and untreated AK, we found significant differences in the expression of interleukin (IL)-6, hurpin, TLR7 and (en)
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| Title
| - Genová exprese u aktinických keratóz: farmakologická modulace imiquimodem (cs)
- Gene expression in actinic keratoses: pharmacological modulation by imiquimod
- Gene expression in actinic keratoses: pharmacological modulation by imiquimod (en)
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| skos:prefLabel
| - Genová exprese u aktinických keratóz: farmakologická modulace imiquimodem (cs)
- Gene expression in actinic keratoses: pharmacological modulation by imiquimod
- Gene expression in actinic keratoses: pharmacological modulation by imiquimod (en)
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| skos:notation
| - RIV/00216208:11120/04:00000964!RIV09-MSM-11120___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/04:00000964
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - actinic keratoses; gene expression; imiquimod; immunomodulation (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - British Journal of Dermatology
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Arenberger, Petr
- Růžička, T.
- Benninghoff, B.
- Hengge, U.R.
- Lysá, B.
- Tartler, U.
- Walz, M.
- Wolf, R.
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| http://linked.open...ain/vavai/riv/wos
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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