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Description
  • Strontium ranelate is a medicine with evidenced effects on the risk of fractures. The heterogeneity of strontium distribution in bone, quality of bone mineral crystals in young bone packets on bone surfaces formed during strontium ranelate administration, and activation of the calcium sensing receptor may, at least partially, explain the beneficial effects of SrR on reducing the risk of fractures. In this review, the concept of the dual action of strontium ranelate is also discussed. However, sufficient evidence for the bone anabolic effect of SrR does not exist in humans. The knowledge of the mechanism of action of SrR is important not only for the explanation of the effects of SrR upon the skeleton, but also for the safety of treatment for other tissues.
  • Strontium ranelate is a medicine with evidenced effects on the risk of fractures. The heterogeneity of strontium distribution in bone, quality of bone mineral crystals in young bone packets on bone surfaces formed during strontium ranelate administration, and activation of the calcium sensing receptor may, at least partially, explain the beneficial effects of SrR on reducing the risk of fractures. In this review, the concept of the dual action of strontium ranelate is also discussed. However, sufficient evidence for the bone anabolic effect of SrR does not exist in humans. The knowledge of the mechanism of action of SrR is important not only for the explanation of the effects of SrR upon the skeleton, but also for the safety of treatment for other tissues. (en)
Title
  • Strontium ranelate: in search for the mechanism of action
  • Strontium ranelate: in search for the mechanism of action (en)
skos:prefLabel
  • Strontium ranelate: in search for the mechanism of action
  • Strontium ranelate: in search for the mechanism of action (en)
skos:notation
  • RIV/00216208:11110/13:10191386!RIV14-MSM-11110___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • V
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 108294
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11110/13:10191386
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • strontium ranelate; dual effect; bone mineral density; osteoporosis (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • JP - Japonsko
http://linked.open...ontrolniKodProRIV
  • [FFC8F529B079]
http://linked.open...i/riv/nazevZdroje
  • Journal of Bone and Mineral Metabolism
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 31
http://linked.open...iv/tvurceVysledku
  • Štěpán, Jan
http://linked.open...ain/vavai/riv/wos
  • 000326924400001
issn
  • 0914-8779
number of pages
http://bibframe.org/vocab/doi
  • 10.1007/s00774-013-0494-1
http://localhost/t...ganizacniJednotka
  • 11110
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