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Description
| - Tracheotomy may be associated with numerous acute and chronic complications including extensive formation of granulation tissue. The emerging functional versatility of the adhesion/growth-regulatory galectins prompted us to perform a histochemical study of wound healing using rat trachea as model. By using non-cross-reactive antibodies and the labelled tissue lectins we addressed the issue of the presence and regulation of galectin reactivity during trachea wound healing. Beside localization of high-molecular-weight keratin, wide-spectrum cytokeratin, keratins 10 and 14, a-smooth muscle actin, vimentin, fibronectin, and Sox-2, galectins -1, -2, and -3 and their reactivity profiles were measured in frozen sections of wounded and control trachea specimens 7, 14, and 28 days after trauma. A clear trend for decreased galectin-1 presence and increased reactivity for galectin-1 was revealed from day 7 to day 28. Sox-2-positive cells were present after seven days and found in the wound bed. Interestingly, several similarities were observed in comparison to skin wound healing including regulation of galectin-1 parameters.
- Tracheotomy may be associated with numerous acute and chronic complications including extensive formation of granulation tissue. The emerging functional versatility of the adhesion/growth-regulatory galectins prompted us to perform a histochemical study of wound healing using rat trachea as model. By using non-cross-reactive antibodies and the labelled tissue lectins we addressed the issue of the presence and regulation of galectin reactivity during trachea wound healing. Beside localization of high-molecular-weight keratin, wide-spectrum cytokeratin, keratins 10 and 14, a-smooth muscle actin, vimentin, fibronectin, and Sox-2, galectins -1, -2, and -3 and their reactivity profiles were measured in frozen sections of wounded and control trachea specimens 7, 14, and 28 days after trauma. A clear trend for decreased galectin-1 presence and increased reactivity for galectin-1 was revealed from day 7 to day 28. Sox-2-positive cells were present after seven days and found in the wound bed. Interestingly, several similarities were observed in comparison to skin wound healing including regulation of galectin-1 parameters. (en)
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Title
| - Early Stages of Trachea Healing Process: (Immuno/Lectin) Histochemical Monitoring of Selected Markers and Adhesion/Growth-Regulatory Endogenous Lectins
- Early Stages of Trachea Healing Process: (Immuno/Lectin) Histochemical Monitoring of Selected Markers and Adhesion/Growth-Regulatory Endogenous Lectins (en)
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skos:prefLabel
| - Early Stages of Trachea Healing Process: (Immuno/Lectin) Histochemical Monitoring of Selected Markers and Adhesion/Growth-Regulatory Endogenous Lectins
- Early Stages of Trachea Healing Process: (Immuno/Lectin) Histochemical Monitoring of Selected Markers and Adhesion/Growth-Regulatory Endogenous Lectins (en)
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skos:notation
| - RIV/00064203:_____/12:8220!RIV13-MZ0-00064203
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http://linked.open...avai/predkladatel
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00064203:_____/12:8220
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - wound healing; tissue repair; regeneration; galectin; glycophenotype; tracheotomy; sugar code; epidermal-cells; expression; skin; galectin-1; carcinoma; binding; rats; complications; functionality (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Gal, P.
- Sabol, F.
- Betka, Jan
- Chovanec, Martin
- Gabius, H. J.
- Kaltner, H.
- Smetana, K.
- Andre, S.
- Frankovicova, M.
- Grendel, T.
- Hudak, V.
- Lences, P.
- Sokolsky, J.
- Vascakova, A.
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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is http://linked.open...avai/riv/vysledek
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