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rdf:type
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Description
| - The purpose of the present study was to investigate the impact of carcinogenic polycyclic aromatic hydrocarbons and volatile organic compounds on sperm quality in a group of city policemen in Prague. Polymorphisms in metabolic genes folic acid metabolism genes and DNA repair genes were evaluated in these men. The study population was a group of 47 policemen working in the center of the city. No significant differences were found in any of the standard semen parameters between the sampling periods except for vitality of sperms. DNA Fragmentation Index (DFI) were significantly higher in winter than in spring samples for all men and for non-smokers. At the bivariate level, significant associations between hDFI or detDFI and polymorphisms of the repair genes XRCC1, XPD6 and XPD23 were observed. In multivariate models, polymorphisms of the genes XPD6, XPD23 and CYP1A1MspI were associated with high DFI and HDS. Moreover, HDS was significantly associated with polymorphisms in GSTM1 gene.
- The purpose of the present study was to investigate the impact of carcinogenic polycyclic aromatic hydrocarbons and volatile organic compounds on sperm quality in a group of city policemen in Prague. Polymorphisms in metabolic genes folic acid metabolism genes and DNA repair genes were evaluated in these men. The study population was a group of 47 policemen working in the center of the city. No significant differences were found in any of the standard semen parameters between the sampling periods except for vitality of sperms. DNA Fragmentation Index (DFI) were significantly higher in winter than in spring samples for all men and for non-smokers. At the bivariate level, significant associations between hDFI or detDFI and polymorphisms of the repair genes XRCC1, XPD6 and XPD23 were observed. In multivariate models, polymorphisms of the genes XPD6, XPD23 and CYP1A1MspI were associated with high DFI and HDS. Moreover, HDS was significantly associated with polymorphisms in GSTM1 gene. (en)
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Title
| - Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution
- Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution (en)
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skos:prefLabel
| - Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution
- Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution (en)
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skos:notation
| - RIV/00027162:_____/10:#0000628!RIV11-AV0-00027162
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(1QS500390506), Z(AV0Z50390512), Z(AV0Z50390703), Z(MZE0002716202)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00027162:_____/10:#0000628
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Gene-environment interaction; Sperm DNA damage; Sperm chromatin structure assay; Genetic susceptibility; Carcinogenic polycyclic aromatic hydrocarbons; Volatile organic compounds (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Rubeš, Jiří
- Solanský, I.
- Přinosilová, Petra
- Rybář, Roman
- Věžník, Zdeněk
- Chvátalová, I.
- Šrám, R. J.
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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is http://linked.open...avai/riv/vysledek
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